Evidence map›Paper›PMID 30982602›Full record

ArticleCell2019

A Compendium of Mutational Signatures of Environmental Agents.

Jill E Kucab, Xueqing Zou, Sandro Morganella, Madeleine Joel, A Scott Nanda, Eszter Nagy, Celine Gomez, Andrea Degasperi, Rebecca Harris, Stephen P Jackson and 3 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06717295 (The CCANED-CIPHER Study), which is not on this map. Cited by 430 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
430citing papers in PubMed, 2 pooled it
26.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06717295 recruitingnot on this mapstarted 2025, after this paper: background citation

The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling

TypeobservationalSponsorJavier ToledoRan2025 to 2028Enrolled6,000ConditionsBrest Cancer, Lung Cancer (NSCLC), Pancreatic Cancer, Adult, Prostate CancersArmsDiNanoQ: A multi-cancer early detection (MCED) blood test, DiNanoTrack: Therapeutic Response Monitoring Blood Test
3 · Its place in the literature

Who cites it

430 citing papers in PubMed, 2 syntheses or guidelines pooled it, 677 citations in OpenAlex.

  1. Pooled it
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370 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Jill E KucabDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, 150 Stamford Street, London SE1 9NH, UK.
Xueqing ZouAcademic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge CB2 9NB, UK; MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Sandro MorganellaWellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Madeleine JoelDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, 150 Stamford Street, London SE1 9NH, UK.
A Scott NandaAcademic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge CB2 9NB, UK.
Eszter NagyDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, 150 Stamford Street, London SE1 9NH, UK.
Celine GomezWellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Andrea DegasperiAcademic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge CB2 9NB, UK; MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Rebecca HarrisAcademic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge CB2 9NB, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Stephen P JacksonThe Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.
Volker M ArltDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, 150 Stamford Street, London SE1 9NH, UK.
David H PhillipsDepartment of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, 150 Stamford Street, London SE1 9NH, UK. Electronic address: david.phillips@kcl.ac.uk.
Serena Nik-ZainalAcademic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge CB2 9NB, UK; MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address: snz@mrc-cu.cam.ac.uk.
King's College London · GBWellcome Sanger Institute · GBUniversity of Cambridge · GBWellcome/Cancer Research UK Gurdon Institute · GB

Funding

Cancer Research UK 18796Cancer Research UK 23433Cancer Research UK 23916Cancer Research UK C313/A14329Cancer Research UK C60100/A23916Wellcome TrustWellcome Trust 101126/B/13/ZWellcome Trust WT100183MA
6 · The paper itself

Abstract

Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed to 79 known or suspected environmental carcinogens. Forty-one yielded characteristic substitution mutational signatures. Some were similar to signatures found in human tumors. Additionally, six agents produced double-substitution signatures and eight produced indel signatures. Investigating mutation asymmetries across genome topography revealed fully functional mismatch and transcription-coupled repair pathways. DNA damage induced by environmental mutagens can be resolved by disparate repair and/or replicative pathways, resulting in an assortment of signature outcomes even for a single agent. This compendium of experimentally induced mutational signatures permits further exploration of roles of environmental agents in cancer etiology and underscores how human stem cell DNA is directly vulnerable to environmental agents. VIDEO ABSTRACT.

Indexed as

Carcinogens, EnvironmentalDNA DamageDNA Mutational AnalysisDNA RepairDNA ReplicationGenetic ProfileGenome, HumanHumansINDEL MutationMutagenesisMutationNeoplasmsPluripotent Stem CellsWhole Genome SequencingCarcinogens, EnvironmentalcarcinogensDNA damageenvironmental mutagensmutagenesisMutational signatures

Identifiers

PMID30982602
PMCPMC6506336
OpenAlexW2938255062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.