ArticleCell2019
Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 135 citations in OpenAlex.
- Protocol for imaging and quantitative analysis of yolk vesicle distribution and movement in syncytial Drosophila embryos.STAR protocols · 2026Article
- Synchronized Chromatin Reorganization as a Key Biomarker in Anesthetic Effects on Plants.Chemical & biomedical imaging · 2026Article
- A phase oscillator model of cell cycles reveals nuclear density control in a branched fungal network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development.The Journal of cell biology · 2026Article
- Elevated temperature fatally disrupts nuclear divisions in the early Drosophila embryo.Nature communications · 2026Article
- Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026Review
- Optimality as a framework for understanding developmental robustness.Trends in cell biology · 2026Review
- Article
- How does cytoplasmic crowding affect reaction rates?Molecular cell · 2026Review
- Start early and pack light: Collaborative adventures in theory and experiment.Seminars in cell & developmental biology · 2025Review
- Optogenetic enzymes: A deep dive into design and impact.Current opinion in structural biology · 2025Review
- Cytoplasmic localization of the mRNA encoding actin regulator, Serendipity-bioRxiv : the preprint server for biology · 2025Article
- Deep learning-based high-resolution time inference for deciphering dynamic gene regulation from fixed embryos.Nature communications · 2025Article
- Capturing CDKs in action: Live-cell biosensors pioneer the new frontiers in cell cycle research.Cell structure and function · 2025Review
- Topological interactions drive the first fate decision in theNature physics · 2025Article
- Analytical methods for cytoplasmic streaming in elongated cells.PNAS nexus · 2025Article
- Nuclear position controls the activity of cortical actomyosin networks powering simultaneous morphogenetic events.Nature communications · 2025Article
- Flow, sense and divide.Nature cell biology · 2025Article
- Cytoplasmic flow is a cell size sensor that scales anaphase.Nature cell biology · 2025Article
- ERK synchronizes embryonic cleavages in Drosophila.Developmental cell · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
The synchronous cleavage divisions of early embryogenesis require coordination of the cell-cycle oscillator, the dynamics of the cytoskeleton, and the cytoplasm. Yet, it remains unclear how spatially restricted biochemical signals are integrated with physical properties of the embryo to generate collective dynamics. Here, we show that synchronization of the cell cycle in Drosophila embryos requires accurate nuclear positioning, which is regulated by the cell-cycle oscillator through cortical contractility and cytoplasmic flows. We demonstrate that biochemical oscillations are initiated by local Cdk1 inactivation and spread through the activity of phosphatase PP1 to generate cortical myosin II gradients. These gradients cause cortical and cytoplasmic flows that control proper nuclear positioning. Perturbations of PP1 activity and optogenetic manipulations of cortical actomyosin disrupt nuclear spreading, resulting in loss of cell-cycle synchrony. We conclude that mitotic synchrony is established by a self-organized mechanism that integrates the cell-cycle oscillator and embryo mechanics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.