Evidence map›Paper›PMID 30982468›Full record

ReviewAddiction science & clinical practice2019

A conceptual model for understanding post-release opioid-related overdose risk.

Paul J Joudrey, Maria R Khan, Emily A Wang, Joy D Scheidell, E Jennifer Edelman, D Keith McInnes, Aaron D Fox

Open access · goldAbstract readReview
In one paragraph

Review in Addiction science & clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 3 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 3 syntheses or guidelines pooled it, 191 citations in OpenAlex.

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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Paul J JoudreyVA Connecticut Healthcare System, West Haven Campus, 950 Campbell Ave, West Haven, CT, 06516, USA. paul.joudrey@gmail.com.ORCID 0000-0001-6448-1526
Maria R KhanDepartment of Population Health, New York University, 227 East 30th Street, New York, NY, 10016, USA.
Emily A WangDepartment of Internal Medicine, Yale School of Medicine, Yale University, 367 Cedar Street, New Haven, CT, USA.
Joy D ScheidellDepartment of Population Health, New York University, 227 East 30th Street, New York, NY, 10016, USA.
E Jennifer EdelmanDepartment of Internal Medicine, Yale School of Medicine, Yale University, 367 Cedar Street, New Haven, CT, USA.
D Keith McInnesDepartment of Veterans Affairs, Center for Healthcare Outcomes and Implementation Research, Edith Nourse Rogers VA Hospital, Bedford, MA, USA.
Aaron D FoxAlbert Einstein College of Medicine, Bronx, NY, 10461, USA.
Yale University · USNew York University · USAlbert Einstein College of Medicine · USBoston University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Transdisciplinary Theoretical Svnthesis and Development CoreP30DA011041 · NIDA · NEW YORK UNIVERSITY · PI Holly Hagan, Courtney McKnight · 1998 to 2026
$38.9M
BEHAVIORAL SCI TRAINING IN DRUG ABUSE RESEARCHT32DA007233 · NIDA · PUBLIC HEALTH SOLUTIONS · PI GOLDSAMT, LLOYD A · 1985 to 2023
$20.2M
NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
Buprenorphine Facilitated Access and Supportive Treatment in Former InmatesK23DA034541 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FOX, AARON D · 2012 to 2016
$913k
NCATS NIH HHS TL1 TR001864NCATS NIH HHS UL1 TR001863NIDA NIH HHS K23DA0345NIDA NIH HHS K23 DA034541NIDA NIH HHS T32 DA007233NIH HHS TL1 TR001864
6 · The paper itself

Abstract

Post-release opioid-related overdose mortality is the leading cause of death among people released from jails or prisons (PRJP). Informed by the proximate determinants framework, this paper presents the Post-Release Opioid-Related Overdose Risk Model. It explores the underlying, intermediate, proximate and biological determinants which contribute to risk of post-release opioid-related overdose mortality. PRJP share the underlying exposure of incarceration and the increased prevalence of several moderators (chronic pain, HIV infection, trauma, race, and suicidality) of the risk of opioid-related overdose. Intermediate determinants following release from the criminal justice system include disruption of social networks, interruptions in medical care, poverty, and stigma which exacerbate underlying, and highly prevalent, substance use and mental health disorders. Subsequent proximate determinants include interruptions in substance use treatment, including access to medications for opioid use disorder, polypharmacy, polydrug use, insufficient naloxone access, and a return to solitary opioid use. This leads to the final biological determinant of reduced respiratory tolerance and finally opioid-related overdose mortality. Mitigating the risk of opioid-related overdose mortality among PRJP will require improved coordination across criminal justice, health, and community organizations to reduce barriers to social services, ensure access to health insurance, and reduce interruptions in care continuity and reduce stigma. Healthcare services and harm reduction strategies, such as safe injection sites, should be tailored to the needs of PRJP. Expanding access to opioid agonist therapy and naloxone around the post-release period could reduce overdose deaths. Programs are also needed to divert individuals with substance use disorder away from the criminal justice system and into treatment and social services, preventing incarceration exposure.

Indexed as

PrisonersChronic PainComorbidityDrug OverdoseFemaleHarm ReductionHealth Services AccessibilityHIV InfectionsHumansMaleMental HealthOpioid-Related DisordersPsychological TraumaRisk AssessmentSocial SupportSocioeconomic FactorsConceptual modelCriminal justice systemMortalityOpioid-related overdose

Identifiers

PMID30982468
PMCPMC6463640
OpenAlexW2937555015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.