ArticleJournal of neuro-oncology2019
Clinical diagnosis of attention-deficit/hyperactivity disorder in survivors of pediatric brain tumors.
Article in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Neurobehavioral outcomes and associated risk factors in pediatric brain tumor survivors.Journal of neuro-oncology · 2026Article
- Attention-deficit/hyperactivity disorder in pediatric cancer survivors: risk and medication use in a nationwide population-based study.Child and adolescent psychiatry and mental health · 2026Article
- An atypical presentation of infiltrative diffuse low-grade glioma in an adolescent: case report.BMC neurology · 2025Article
- Late effects of medulloblastoma treatment: multidisciplinary approach of survivors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Review
- Association of Perinatal and Childhood Ischemic Stroke With Attention-Deficit/Hyperactivity Disorder.JAMA network open · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeSurvivors of pediatric brain tumors often have neurodevelopmental late effects, such as inattention. Symptoms may mirror those of attention-deficit/hyperactivity disorder (ADHD), which affects ~ 5-8% of the general population. This retrospective study of survivors followed at a large tertiary care center examined the prevalence of a clinical diagnosis of ADHD, and risk factors associated with ADHD diagnosis and ADHD-related medication use.
methodsA retrospective chart review of brain tumor survivors (n = 528), diagnosed between 2000 and 2015, who were at least 6 years old and 2 years from the end of tumor-directed therapy or from diagnosis, if no interventions were received. Clinical and demographic data were extracted from the medical record.
resultsSurvivors were 55.7% male with mean age 8.15 ± 4.4 (0.0-16.0) years at brain tumor diagnosis. The most common diagnoses were low-grade glioma, medulloblastoma, and craniopharyngioma, with 52.5% of tumors supratentorial. Of the survivors, 81.3% received surgery, 40.0% radiation therapy, and 36.6% chemotherapy. Sixty-nine survivors (13.1%) had ADHD diagnoses, 105 (19.9%) had symptoms of ADHD without diagnoses, and 64 (12.1%) had ADHD medication use. ADHD diagnosis was associated with younger age at tumor diagnosis (p = 0.05) and supratentorial tumor location (p = 0.001). ADHD diagnosis was not associated with gender, tumor type, or treatment type.
conclusionsSurvivors of brain tumors are at increased risk of ADHD and related symptoms. The greatest increase in risk occurs for survivors with diagnoses at younger ages and supratentorial tumors. Additional research is warranted, as select survivors may benefit from behavioral or pharmacologic ADHD treatments to optimize functioning.
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