ArticlePsychopharmacology2019
The computational pharmacology of oculomotion.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Digital measurement of ocular microtremor in Parkinson's Disease: Analytical and clinical validation.PLOS digital health · 2026Article
- Active Inference and Functional Parametrisation: Differential Flatness and Smooth Random Realisation.Entropy (Basel, Switzerland) · 2026Article
- The active construction of past episodes.Translational neuroscience · 2026Article
- Deep Hybrid Models: Infer and Plan in a Dynamic World.Entropy (Basel, Switzerland) · 2025Article
- Conscious active inference I: A quantum model naturally implements the path integral needed for real-time planning and control.Computational and structural biotechnology journal · 2025Review
- Article
- A regulatory pathway model of neuropsychological disruption in Havana syndrome.Frontiers in psychiatry · 2023Article
- Active inference, selective attention, and the cocktail party problem.Neuroscience and biobehavioral reviews · 2021Review
- Memory and Markov Blankets.Entropy (Basel, Switzerland) · 2021Article
- The computational neurology of movement under active inference.Brain : a journal of neurology · 2021Article
- Active inference on discrete state-spaces: A synthesis.Journal of mathematical psychology · 2020Review
- Modules or Mean-Fields?Entropy (Basel, Switzerland) · 2020Article
- Generalised free energy and active inference.Biological cybernetics · 2019Article
- Editorial: bridging the gap with computational and translational psychopharmacology.Psychopharmacology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many physiological and pathological changes in brain function manifest in eye-movement control. As such, assessment of oculomotion is an invaluable part of a clinical examination and affords a non-invasive window on several key aspects of neuronal computation. While oculomotion is often used to detect deficits of the sort associated with vascular or neoplastic events; subtler (e.g. pharmacological) effects on neuronal processing also induce oculomotor changes. We have previously framed oculomotor control as part of active vision, namely, a process of inference comprising two distinct but related challenges. The first is inferring where to look, and the second is inferring how to implement the selected action. In this paper, we draw from recent theoretical work on the neuromodulatory control of active inference. This allows us to simulate the sort of changes we would expect in oculomotor behaviour, following pharmacological enhancement or suppression of key neuromodulators-in terms of deciding where to look and the ensuing trajectory of the eye movement itself. We focus upon the influence of cholinergic and GABAergic agents on the speed of saccades, and consider dopaminergic and noradrenergic effects on more complex, memory-guided, behaviour. In principle, a computational approach to understanding the relationship between pharmacology and oculomotor behaviour affords the opportunity to estimate the influence of a given pharmaceutical upon neuronal function, and to use this to optimise therapeutic interventions on an individual basis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.