Evidence map›Paper›PMID 30982100›Full record

Trial reportEuropean journal of applied physiology2019

Four weeks of probiotic supplementation reduces GI symptoms during a marathon race.

Jamie N Pugh, Andy S Sparks, Dominic A Doran, Simon C Fleming, Carl Langan-Evans, Ben Kirk, Robert Fearn, James P Morton, Graeme L Close

3 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 67 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 15 pooled it
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04530929 nacompletednot on this map

Analysis of the Impact of Used Probiotic Strains and Diet on Body Composition, Cardiopulmonary Efficiency and the Incidence of Gastrointestinal Disorders in Runners

TypeinterventionalSponsorMedical University of BialystokRan2018 to 2018Enrolled66ConditionsGastrointestinal Disorder, FunctionalArmsSANPROBI BARRIER, PLACEBO
NCT06230991 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

A Pilot Study of Efficacy and Safety of a Microbiome Immunity Formula (SIM05) in Adults With Atopic Eczema

TypeinterventionalSponsorChinese University of Hong KongRan2023 to 2025Enrolled30ConditionsAtopic EczemaArmsSIM05
NCT07366931 phase1 / phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized, Placebo-controlled, Double-blind Trial on the Effect of Daily Supplementation With Humiome® Post LB on Gastrointestinal Symptoms in Female Athletes

TypeinterventionalSponsorLiverpool John Moores UniversityRan2026 to 2026Enrolled100ConditionsHealthy Adult Females, Gastrointestinal SymptomsArmsPostbiotic, Placebo
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 15 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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  7. Effects of Probiotics Supplementation on Risk and Severity of Infections in Athletes: A Systematic Review.International journal of environmental research and public health · 2022
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  14. Impact of Probiotics on the Performance of Endurance Athletes: A Systematic Review.International journal of environmental research and public health · 2021
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Jamie N PughResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom St Campus, Liverpool, L3 3AF, UK.
Andy S SparksSport Nutrition and Performance Research Group, Department of Sport and Physical Activity, Edge Hill University, Ormskirk, UK.
Dominic A DoranResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom St Campus, Liverpool, L3 3AF, UK.
Simon C FlemingRoyal Cornwall Hospital, Truro, UK.
Carl Langan-EvansResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom St Campus, Liverpool, L3 3AF, UK.
Ben KirkSchool of Health Sciences, Liverpool Hope University, Liverpool, UK.
Robert FearnHomerton University Hospital NHS Foundation Trust, London, UK.
James P MortonResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom St Campus, Liverpool, L3 3AF, UK.
Graeme L CloseResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom St Campus, Liverpool, L3 3AF, UK. g.l.close@ljmu.ac.uk.
Liverpool John Moores University · GBEdge Hill University · GBHomerton University Hospital NHS Foundation Trust · GBLiverpool Hope University · GBRoyal Cornwall Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effects of probiotic supplementation on gastrointestinal (GI) symptoms, circulatory markers of GI permeability, damage, and markers of immune response during a marathon race.

methodsTwenty-four recreational runners were randomly assigned to either supplement with a probiotic (PRO) capsule [25 billion CFU Lactobacillus acidophilus (CUL60 and CUL21), Bifidobacterium bifidum (CUL20), and Bifidobacterium animalis subs p. Lactis (CUL34)] or placebo (PLC) for 28 days prior to a marathon race. GI symptoms were recorded during the supplement period and during the race. Serum lactulose:rhamnose ratio, and plasma intestinal-fatty acid binding protein, sCD14, and cytokines were measured pre- and post-races.

resultsPrevalence of moderate GI symptoms reported were lower during the third and fourth weeks of the supplement period compared to the first and second weeks in PRO (p < 0.05) but not PLC (p > 0.05). During the marathon, GI symptom severity during the final third was significantly lower in PRO compared to PLC (p = 0.010). The lower symptom severity was associated with a significant difference in reduction of average speed from the first to the last third of the race between PLC (- 14.2 ± 5.8%) and PRO (- 7.9 ± 7.5%) (p = 0.04), although there was no difference in finish times between groups (p > 0.05). Circulatory measures increased to a similar extent between PRO and PLC (p > 0.05).

conclusionProbiotics supplementation was associated with a lower incidence and severity of GI symptoms in marathon runners, although the exact mechanisms are yet to be elucidated. Reducing GI symptoms during marathon running may help maintain running pace during the latter stages of racing.

Indexed as

AdultBifidobacteriumCytokinesFatty Acid-Binding ProteinsFemaleGastrointestinal DiseasesGastrointestinal TractHumansJoggingLactobacillus acidophilusLactoseLipopolysaccharide ReceptorsMaleProbioticsRhamnoseCytokinesFatty Acid-Binding ProteinsLactoseLipopolysaccharide ReceptorsRhamnoseExercise performanceGastrointestinalMarathonProbiotics

Identifiers

PMID30982100
PMCPMC6570661
OpenAlexW2938910027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.