Evidence map›Paper›PMID 30982080›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2019

Antidepressant-like effect and toxicological parameters of extract and withanolides isolated from aerial parts of Solanum capsicoides All. (Solanaceae).

Marcel Petreanu, Paula Maia, Janieire L da Rocha Pittarello, Lucimara C Loch, Franco Delle Monache, Alice L Perez, Godofredo Solano-Arias, Valdir Cechinel Filho, Márcia Maria de Souza, Rivaldo Niero

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Antioxidant-RichPlants (Basel, Switzerland) · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marcel PetreanuPrograma de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, 88303-901, Brazil.
Paula MaiaPrograma de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, 88303-901, Brazil.
Janieire L da Rocha PittarelloPrograma de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, 88303-901, Brazil.
Lucimara C LochPrograma de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, 88303-901, Brazil.
Franco Delle MonachePrograma de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, 88303-901, Brazil.
Alice L PerezCentro de Investigación en Productos Naturales (CIPRONA), Universidad de Costa Rica (UCR), San José, Costa Rica.
Godofredo Solano-AriasCentro de Investigación en Productos Naturales (CIPRONA), Universidad de Costa Rica (UCR), San José, Costa Rica.
Valdir Cechinel FilhoPrograma de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, 88303-901, Brazil.
Márcia Maria de SouzaPrograma de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, 88303-901, Brazil.
Rivaldo NieroPrograma de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, 88303-901, Brazil. niero@univali.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present work describes the evaluation of the antidepressant-like activity of the extract, fractions, and compounds obtained from the aerial parts of Solanum capsicoides. The methanolic extract (MESC) obtained by conventional maceration was partitioned with solvents of increasing polarities yielding the respective fractions of hexane (HE), dichloromethane (DCM), and ethyl acetate (EA). The dichloromethane and ethyl acetate fractions were submitted to chromatographic and spectroscopic techniques, leading to the isolation and identification of cilistadiol (1), astragalin (2), and cilistol A (3). In relation to the antidepressant activity, the extract was active against the forced swimming test (FST) at a concentration of 300 mg/kg an ED

Indexed as

AnimalsAntidepressive AgentsBehavior, AnimalDose-Response Relationship, DrugFemaleHindlimb SuspensionMethylene ChlorideMiceMotor ActivityPlant Components, AerialPlant ExtractsSolanumSolventsSwimmingWithanolidesAntidepressive AgentsMethylene ChloridePlant ExtractsSolventsWithanolidesAntidepressant-like activitySolanum capsicoidesWithanolides

Identifiers

PMID30982080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.