ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2019
Dorsal root ganglion stimulation for chronic pain modulates Aβ-fiber activity but not C-fiber activity: A computational modeling study.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Peripheral nerve stimulation targeting the trochanteric branch of the femoral nerve for refractory greater trochanteric pain syndrome followed by dorsal root ganglion stimulation: A case report and mechanistic perspective.Interventional pain medicine · 2026Article
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Article
- Spinal neuron-glial crosstalk and ion channel dysregulation in diabetic neuropathic pain.Frontiers in immunology · 2025Review
- Tonic Stimulation of Dorsal Root Ganglion Results in Progressive Decline in Recruitment of Aα/β-Fibers in Rats.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
- The effects of neuron morphology and spatial distribution on the selectivity of dorsal root ganglion stimulation.Journal of neural engineering · 2024Article
- A preliminary study exploring the effects of transcutaneous spinal cord stimulation on spinal excitability and phantom limb pain in people with a transtibial amputation.Journal of neural engineering · 2024Article
- Research hotspots and trends of spinal cord stimulation for neuropathic pain: a bibliometric analysis from 2004 to 2023.Perioperative medicine (London, England) · 2024Review
- Photobiomodulation for pain relief: Model-based estimates of effective doses of light at the neural target.Journal of photochemistry and photobiology. B, Biology · 2024Article
- Computational modeling of dorsal root ganglion stimulation using an Injectrode.Journal of neural engineering · 2024Article
- Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: a computational modeling study.Journal of neurophysiology · 2024Article
- Advanced neuroprosthetic electrode design optimized by electromagnetic finite element simulation: innovations and applications.Frontiers in bioengineering and biotechnology · 2024Review
- Comparison of the efficacy of spinal cord stimulation and dorsal root ganglion stimulation in the treatment of painful diabetic peripheral neuropathy: a prospective, cohort-controlled study.Frontiers in neurology · 2024Article
- Model-based analysis of subthreshold mechanisms of spinal cord stimulation for pain.Journal of neural engineering · 2023Article
- The role of protein kinases in diabetic neuropathic pain: an update review.Journal of diabetes and metabolic disorders · 2023Review
- Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.Journal of neuroengineering and rehabilitation · 2022Review
- Dorsal Root Ganglion Stimulation for Chronic Pain: Hypothesized Mechanisms of Action.The journal of pain · 2022Review
- Dorsal root ganglion stimulation produces differential effects on action potential propagation across a population of biophysically distinct C-neurons.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Lumbar trans-spinal direct current stimulation: A modeling-experimental approach to dorsal root ganglia stimulation.Frontiers in neuroscience · 2022Article
- Stimulation of the dorsal root ganglion using an InjectrodeJournal of neural engineering · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe goal of this project was to use computational models to investigate which types of primary sensory neurons are modulated by dorsal root ganglion stimulation (DRGS) to provide pain relief.
methodsWe modeled DRGS by coupling an anatomical finite element model of a human L5 dorsal root ganglion to biophysical models of primary sensory neurons. We calculated the stimulation amplitude needed to elicit an action potential in each neuron, and examined how DRGS affected sensory neuron activity.
resultsWe showed that within clinical ranges of stimulation parameters, DRGS drives the activity of large myelinated Aβ-fibers but does not directly activate small nonmyelinated C-fibers. We also showed that the position of the active and return electrodes and the polarity of the stimulus pulse influence neural activation.
conclusionsOur results indicate that DRGS may provide pain relief by activating pain-gating mechanisms in the dorsal horn via repeated activation of large myelinated afferents. SIGNIFICANCE: Understanding the mechanisms of action of DRGS-induced pain relief may lead to innovations in stimulation technologies that improve patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.