Evidence map›Paper›PMID 30981737›Full record

SynthesisNeuroscience and biobehavioral reviews2019

DNA methylation studies of depression with onset in the peripartum: A critical systematic review.

Sarah Ellen Braun, Dana Lapato, Roy E Brown, Eva Lancaster, Timothy P York, Ananda B Amstadter, Patricia A Kinser

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sarah Ellen BraunDepartment of Psychology, Virginia Commonwealth University, Richmond, VA 23284, USA.
Dana LapatoDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.
Roy E BrownTompkins-McCaw Library for the Health Sciences, Virginia Commonwealth University, 509 N. 12th Street, Richmond, VA 23298, USA.
Eva LancasterDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.
Timothy P YorkDepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA; Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Ananda B AmstadterDepartment of Psychology, Virginia Commonwealth University, Richmond, VA 23284, USA; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA; Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Patricia A KinserSchool of Nursing, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address: kinserpa@vcu.edu.
Virginia Commonwealth University · US

Funding

VCU NIMHD Comprehensive Center of Excellence (Project 1; PI: Strauss)P60MD002256 · NIMHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI CONEY, PONJOLA · 2007 to 2016
$13.1M
Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
Stress-induced drinking in Returning Soldiers: Genetic and Epigenetic MechanismsK02AA023239 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI AMSTADTER, ANANDA B · 2014 to 2018
$643k
NCATS NIH HHS UL1 TR000058NIAAA NIH HHS K02 AA023239NIMHD NIH HHS P60 MD002256NIMH NIH HHS L30 MH107994NIMH NIH HHS T32 MH020030
6 · The paper itself

Abstract

objectiveMajor depression with peripartum onset (MDP) has been associated with multiple adverse offspring health outcomes. The biological mechanisms underlying this relationship remain unclear, but DNA methylation (DNAm) represents a plausible mechanism for mediating MDP exposures and changes in offspring development, behavior, and health. Advances in DNAm research necessitate reevaluating the MDP-DNAm literature to determine how well past studies conform with current best practices.

methodFive databases were searched to identify studies of prenatal-onset MDP and DNAm. Quality scores were assigned to each article independently by two raters using a novel scale specific for MDP-DNAm research.

resultsNineteen studies met inclusion criteria. Quality scores ranged from 10 to 17 out of 24 points (M = 12.8; SD = 1.9), with higher scores indicating increased study rigor. Poor covariate reporting was the most significant contributor to lower scores.

conclusionNo longitudinal MDP-DNAm studies exist. Earlier MDP-DNAm studies should be interpreted with caution, and future research must commit to sharing methodology and data to facilitate cross-study comparisons and maximize dataset utility.

Indexed as

DNA MethylationEpigenomicsMajor Depressive DisorderPeripartum PeriodPregnancy ComplicationsReproducibility of ResultsFemaleHumansPregnancyDNA methylationEpigeneticsMajor depressionPregnancyPrenatal maternal depressionReproducibility

Identifiers

PMID30981737
PMCPMC6556411
OpenAlexW2935751535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.