ArticleNeuron2019
Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
62 citing papers in PubMed, 112 citations in OpenAlex.
- Article
- Mating imperatives drive plasticity of the daily temporal niche in fruit flies.Nature ecology & evolution · 2026Article
- Circadian Rhythms Time Seizure Severity inJournal of biological rhythms · 2026Article
- Genomic signature of repeated transitions to diurnality in spiders.Molecular biology and evolution · 2026Article
- Review
- The use ofFrontiers in cell and developmental biology · 2026Review
- Global Research Trends and Hotspots in Cardiac Devices: A Bibliometric and Visual Analysis.Healthcare (Basel, Switzerland) · 2025Review
- Article
- Cell type-specific driver lines targeting theeLife · 2025Article
- Spatiotemporal computations in the insect celestial compass.Nature communications · 2025Article
- Neuropeptide-Dependent Spike Time Precision and Plasticity in Circadian Output Neurons.The European journal of neuroscience · 2025Article
- Cell type-specific driver lines targeting thebioRxiv : the preprint server for biology · 2025Article
- Choosing which models best explain photoperiodic time measurement mechanisms in plants.Npj biological timing and sleep · 2025Review
- A four-oscillator model of seasonally adapted morning and evening activities in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- A subclass of evening cells promotes the switch from arousal to sleep at dusk.Current biology : CB · 2024Article
- Single-cell transcriptomics reveals that glial cells integrate homeostatic and circadian processes to drive sleep-wake cycles.Nature neuroscience · 2024Article
- Scientific experimental articles are modernist stories.European journal for philosophy of science · 2024Article
- Task-specific odorant receptor expression in worker antennae indicates that sensory filters regulate division of labor in ants.Communications biology · 2023Article
- Circadian clock disruption promotes the degeneration of dopaminergic neurons in male Drosophila.Nature communications · 2023Article
- Examining Sleep Modulation byeNeuro · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Many animals exhibit morning and evening peaks of locomotor behavior. In Drosophila, two corresponding circadian neural oscillators-M (morning) cells and E (evening) cells-exhibit a corresponding morning or evening neural activity peak. Yet we know little of the neural circuitry by which distinct circadian oscillators produce specific outputs to precisely control behavioral episodes. Here, we show that ring neurons of the ellipsoid body (EB-RNs) display spontaneous morning and evening neural activity peaks in vivo: these peaks coincide with the bouts of locomotor activity and result from independent activation by M and E pacemakers. Further, M and E cells regulate EB-RNs via identified PPM3 dopaminergic neurons, which project to the EB and are normally co-active with EB-RNs. These in vivo findings establish the fundamental elements of a circadian neuronal output pathway: distinct circadian oscillators independently drive a common pre-motor center through the agency of specific dopaminergic interneurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.