Evidence map›Paper›PMID 30981489›Full record

ArticleJournal of dairy science2019

Effect of dietary supplementation of sodium acetate and calcium butyrate on milk fat synthesis in lactating dairy cows.

N Urrutia, R Bomberger, C Matamoros, K J Harvatine

Open access · bronzeAbstract readClinical Trial, Veterinary
In one paragraph

Article in Journal of dairy science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Effects ofAnimals : an open access journal from MDPI · 2026
    Article
  3. Applications and Action Mechanisms ofAnimals : an open access journal from MDPI · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Study on the mechanism of SAR1B in sodium acetate promoting milk fat synthesis.In vitro cellular & developmental biology. Animal · 2025
    Article
  14. Optimization ofFrontiers in microbiology · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

N UrrutiaInstituto de Investigaciones Agropecuarias, INIA Remehue, Osorno, Los Lagos 5290000, Chile.
R BombergerDepartment of Animal Science, The Pennsylvania State University, University Park 16802.
C MatamorosDepartment of Animal Science, The Pennsylvania State University, University Park 16802.
K J HarvatineDepartment of Animal Science, The Pennsylvania State University, University Park 16802. Electronic address: kjh182@psu.edu.
Pennsylvania State University · USInstituto de Investigaciones Agropecuarias · CL

Funding

Research Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2M
NIGMS NIH HHS T32 GM108563
6 · The paper itself

Abstract

Acetate is a major source of energy and substrate for milk fat synthesis in the dairy cow. We recently reported a linear increase in milk fat yield and greater than a 30% net apparent transfer of acetate to milk fat with ruminal infusion of neutralized acetate. Additionally, ruminal acetate infusion linearly increases plasma β-hydroxybutyrate. The objective of the current study was to investigate the ability of acetate and butyrate fed in a diet to increase milk fat synthesis. Twelve multiparous lactating Holstein cows were randomly assigned to treatments in a 3 × 3 Latin square design with 14-d periods that included a 7-d washout followed by 7 d of treatment. Cows were fed ad libitum a basal diet with a low risk for biohydrogenation-induced milk fat depression, and treatments were mixed into the basal diet. Treatments were 3.2% NaHCO

Indexed as

CattleDietary SupplementsAnimal FeedAnimalsDairyingDietFatty AcidsFemaleIsobutyratesLactationMilkRandom AllocationSodium AcetateFatty AcidsIsobutyratesisobutyric acidSodium Acetateacetatebutyratedairy cowmilk fat synthesis

Identifiers

PMID30981489
PMCPMC6564677
OpenAlexW2939617731

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.