Evidence map›Paper›PMID 30981443›Full record

ArticleTrends in neurosciences2019

Axon Guidance Molecules Implicated in Early-Onset Obesity.

Lori M Zeltser

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. The Role of Semaphorins in Metabolic Disorders.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Lori M ZeltserNaomi Berrie Diabetes Center, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA. Electronic address: lz146@cumc.columbia.edu.
Columbia University · US

Funding

Functional mapping of arginine vasopressin receptor 1A circuits that promote anorexic behaviorR01MH113353 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZELTSER, LORI M · 2018 to 2022
$2.3M
Developmental programming of brown adipose tissue sympathetic toneR01DK125094 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZELTSER, LORI M · 2020 to 2023
$2.1M
NIDDK NIH HHS R01 DK125094NIMH NIH HHS R01 MH113353
6 · The paper itself

Abstract

Maternal nutritional status and the early growth rates of offspring influence the development of the melanocortin system and later susceptibility to metabolic dysregulation, but it is difficult to assess causality. A recent study by van der Klaauw et al. (Cell 2019;176:729-742) provides direct evidence that disrupting systems regulating neuronal circuit formation leads to early-onset obesity in zebrafish, mouse, and humans.

Indexed as

SemaphorinsAnimalsAxon GuidanceHumansMelanocortinsMiceNerve Tissue ProteinsObesitySignal TransductionMelanocortinsNerve Tissue ProteinsSemaphorinsaxon guidanceearly-onset obesityhypothalamusplexinssemaphorins

Identifiers

PMID30981443
OpenAlexW2939483730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.