ArticleiScience2019
BODIPY-Decorated Nanoscale Covalent Organic Frameworks for Photodynamic Therapy.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Potential of Covalent Organic Framework in Pharmacy and Biomedicine: Influence of Structure on Properties and Applications.ChemMedChem · 2026Review
- Insights into Sensing and Biomedical Domains Using Multi-Synthetic Covalent Organic Frameworks.Biosensors · 2026Review
- Multicolored, Sonosensitizer-Optimized Organic Mechanoluminescent Nanoparticles for Functional Sono-Optogenetics.Journal of the American Chemical Society · 2026Article
- Red-Light Activable Oxovanadium(IV)-Gold Nanoparticles (VO@AuNPs) for Next-Generation Photodynamic Therapy: Design, Photophysics, and Therapeutic Evaluation.Chemistry, an Asian journal · 2026Article
- Exploration of covalent-organic frameworks and metal-organic frameworks for drug delivery applications.Frontiers in chemistry · 2026Review
- Encapsulation of a Highly Acid-Stable Dicyano-Bodipy in Zr-Based Metal-Organic Frameworks with Increased Fluorescence Lifetime and Quantum Yield Within the Solid Solution Concept.Molecules (Basel, Switzerland) · 2025Article
- Nanoparticles of non-porphyrinic covalent organic frameworks as contrast agents for photoacoustic imaging.Scientific reports · 2025Article
- Fighting Cancer with Photodynamic Therapy and Nanotechnologies: Current Challenges and Future Directions.International journal of molecular sciences · 2025Review
- Covalent organic frameworks in cancer theranostics: advancing biomarker detection and tumor-targeted therapy.Archives of pharmacal research · 2025Review
- Controlling crystallization in covalent organic frameworks to facilitate photocatalytic hydrogen production.Nature communications · 2025Article
- Hybrid Nanoplatforms Based on Photosensitizers and Metal/Covalent Organic Frameworks for Improved Cancer Synergistic Treatment Nano-Delivery Systems.Molecules (Basel, Switzerland) · 2025Review
- Covalent organic frameworks for cancer immunotherapy: mechanisms, applications, and prospects.Frontiers in immunology · 2025Review
- Probing Defects in Covalent Organic Frameworks.ACS applied materials & interfaces · 2024Review
- Article
- Covalent-Organic Framework-Based Materials in Theranostic Applications: Insights into Their Advantages and Challenges.ACS omega · 2024Review
- An erythrocyte membrane-camouflaged fluorescent covalent organic framework for starving/nitric oxide/immunotherapy of triple-negative breast cancer.Chemical science · 2023Article
- Near-infrared photodynamic and photothermal co-therapy based on organic small molecular dyes.Journal of nanobiotechnology · 2023Review
- Functionalization of BODIPY Dyes with Additional C-N Double Bonds and Their Applications.Topics in current chemistry (Cham) · 2023Review
- Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy.Nature communications · 2023Article
- In Vivo Fluorescence Molecular Imaging Using Covalent Organic Nanosheets Without Labeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Covalent organic frameworks (COFs), an emerging class of organic porous materials, have attracted intense attention due to their versatile applications. However, the deliberate fabrication of COF-based nanomaterials for nanomedical application remains challenging due to difficulty in their size- and structure-controlled synthesis and poor aqueous dispersibility. Herein, we report two boron-dipyrromethene (BODIPY)-decorated nanoscale COFs (NCOFs), which were prepared by the Schiff-base condensation of the free end -CHO (bonding defects in COFs) on the established imine-based NCOFs with the amino-substituted organic photosensitizer BODIPY via "bonding defects functionalization" approach. Thus BODIPY has been successfully nanocrystallized via the NCOF platform, and can be used for photodynamic therapy (PDT) to treat tumors. These NCOF-based PDT agents featured nanometer size (∼110 nm), low dark toxicity, and high phototoxicity as evidenced by in vitro and in vivo experiments. Moreover, the "bonding defects functionalization" approach might open up new avenues for the fabrication of additional COF-based platforms for biomedical treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.