Evidence map›Paper›PMID 30980938›Full record

ArticleActa biomaterialia2019

Nitric oxide releasing poly(vinylidene fluoride-co-hexafluoropropylene) films using a fluorinated nitric oxide donor to greatly decrease chemical leaching.

Yang Zhou, Jinyi Tan, Jianfeng Wu, Qi Zhang, John Andre, Chuanwu Xi, Zhan Chen, Mark E Meyerhoff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yang ZhouDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Jinyi TanDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Jianfeng WuDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Qi ZhangDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
John AndreDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Chuanwu XiDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Zhan ChenDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Mark E MeyerhoffDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mmeyerho@umich.edu.
University of Michigan · US

Funding

Bactericidal, Nonthrombogenic Intravascular CathetersR01HL128337 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARTLETT, ROBERT H., MEYERHOFF, MARK E · 2015 to 2018
$2.8M
NHLBI NIH HHS R01 HL128337
6 · The paper itself

Abstract

Nitric oxide (NO) releasing polymers have been widely applied as biomaterials for a variety of biomedical implants and devices. However, the chemical leaching of NO donors and their byproduct species is almost always observed during the application of polymers doped with NO donors, unless the donor is covalently linked to the polymer. Herein, we report the first NO releasing poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) fluorinated copolymer prepared by incorporating a fluorinated S-nitrosothiol as the NO donor. Under physiological conditions, the resulting polymeric films can release NO for 16 days. Importantly, due to both fluorine-fluorine and electrostatic charge interactions between the fluorinated NO donor and the PVDF-HFP copolymer, the total chemical leaching of the fluorinated NO donor and its disulfide product after 9 day was only 0.6% (mol%) of the initial amount of NO donor loaded into the film. These new NO release PVDF-HFP films exhibit antimicrobial and anti-biofilm activities against both Gram positive S. aureus and Gram negative P. aeruginosa strains. The NO-releasing PVDF-HFP polymer can also be coated on Teflon tubing to release NO under physiological conditions for extended time periods. This NO-releasing PVDF-HFP copolymer with greatly reduced chemical leaching could help enhance the biocompatibility and antimicrobial activity of various biomedical devices. STATEMENT OF SIGNIFICANCE: Fluoropolymers have been widely used in creating various biomedical implants and devices. However, nitric oxide (NO) release fluoropolymers have not been well studied to date. Additionally, in the application of biomaterials doped with NO donors, a significant amount of NO donors and their byproducts almost always leach into aqueous environment. We now report an NO releasing poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) fluoropolymer by incorporating a new fluorinated S-nitrosothiol. The NO release can last for 16 days under physiological conditions. The total chemical leaching was determined to be only 0.6 mol% of the initial S-nitrosothiol loaded. As expected, significant antimicrobial/anti-biofilm activities of the NO release PVDF-HFP film were observed against Gram positive S. aureus and Gram negative P. aeruginosa bacterial strains.

Indexed as

Membranes, ArtificialAnti-Bacterial AgentsBiofilmsNitric OxideNitric Oxide DonorsPseudomonas aeruginosaStaphylococcus aureusVinyl CompoundsAnti-Bacterial AgentsMembranes, ArtificialNitric OxideNitric Oxide DonorsVinyl CompoundsAntibacterial activityChemical leachingFluoropolymerNitric oxide releasingPoly(vinylidene fluoride-co-hexafluoropropylene)

Identifiers

PMID30980938
PMCPMC6513704
OpenAlexW2937746282

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.