ReviewPhysiology & behavior2019
Motivation to eat and not to eat - The psycho-biological conflict in anorexia nervosa.
Review in Physiology & behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05368844 (Harnessing Neurostimulation to Improve Treatment Outcome in Anorexia Nervosa), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Harnessing Neurostimulation to Improve Treatment Outcome in Anorexia Nervosa
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurosurgery and neuromodulation for anorexia nervosa in the 21st century: a systematic review of treatment outcomes.Eating disordersPooled it
- Anxiety-metabolism networks in human anorexia nervosa: Responses to caloric and non-caloric meals in the Networks Integrating Anxiety and Metabolism in Anorexia Nervosa (NAMA) randomized trial.The British journal of nutrition · 2026Trial
- Neuroimaging of hypothalamic mechanisms related to glucose metabolism in anorexia nervosa and obesity.The Journal of clinical investigation · 2020Trial
- A neurodevelopmental model of eating disorder risk in midlife to older adulthood.Neuroscience and biobehavioral reviews · 2026Review
- Ketone Supplementation Attenuates Prediction Error Taste Response in Eating Disorders: A Proof-of-Concept Study.The International journal of eating disorders · 2026Article
- Annual Research Review: Neural mechanisms of eating disorders in youth - from current theory and findings to future directions.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Metabolic regulation of synaptic plasticity in anorexia nervosa.Frontiers in synaptic neuroscience · 2026Review
- From lobotomy to connectomics: a critical review of contemporary psychosurgery.Frontiers in psychiatry · 2026Review
- Key features of illness and treatment experiences in longstanding anorexia nervosa: qualitative descriptive study.BJPsych open · 2025Article
- A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization.Scientific reports · 2025Article
- Weight restoration in patients with anorexia nervosa after stereotactic surgery and brain morphometric insights.BMC psychiatry · 2025Article
- Healthy or skinny? The negotiation between fear appeal and danmu in anorexia awareness videos.Journal of eating disorders · 2025Article
- Pharmacotherapeutic strategies for the treatment of anorexia nervosa - novel targets to break a vicious cycle.Expert opinion on pharmacotherapy · 2024Review
- How Do Patients and Their Supports Experience Temperament Based Therapy With Support (TBT-S)? A Qualitative Study.The International journal of eating disorders · 2024Article
- Article
- Why Don't You Just Eat? Neuroscience and the Enigma of Eating Disorders.Focus (American Psychiatric Publishing) · 2024Article
- Deployment of attention to facial expressions varies as a function of emotional quality-but not in alexithymic individuals.Frontiers in psychiatry · 2024Article
- Affective profiles of exercise episodes are associated with maladaptive and adaptive motivations for exercise.European eating disorders review : the journal of the Eating Disorders Association · 2023Article
- Systematic review of prospective studies assessing risk factors to predict anorexia nervosa onset.Journal of eating disorders · 2023Review
- A systematic review of people's lived experiences of inpatient treatment for anorexia nervosa: living in a "bubble".Journal of eating disorders · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Anorexia nervosa is a severe psychiatric illness with high mortality. Brain imaging research has indicated altered reward circuits in the disorder. Here we propose a disease model for anorexia nervosa, supported by recent studies, that integrates psychological and biological factors. In that model, we propose that there is a conflict between the conscious motivation to restrict food, and a body-homeostasis driven motivation to approach food in response to weight loss. These opposing motivations trigger anxiety, which maintains the vicious cycle of ongoing energy restriction and weight loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.