Evidence map›Paper›PMID 30980772›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2019

The future of organ perfusion and re-conditioning.

Annemarie Weissenbacher, Georgios Vrakas, David Nasralla, Carlo D L Ceresa

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 3 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. Normothermic Regional Perfusion in Controlled Donation After Circulatory Death Liver Transplantation: A Systematic Review and Meta-Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Pooled it
  3. Hospital-Based Health Technology Assessment of Machine Perfusion Systems for Human Liver Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2022
    Pooled it
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  8. Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool.Transplant international : official journal of the European Society for Organ Transplantation · 2026
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Annemarie WeissenbacherDepartment of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0000-0002-0582-1815
Georgios VrakasNuffield Department of Surgical Sciences, Oxford Transplant Centre, Churchill Hospital, Oxford University Hospitals, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-9108-4064
David NasrallaNuffield Department of Surgical Sciences, Oxford Transplant Centre, Churchill Hospital, Oxford University Hospitals, University of Oxford, Oxford, UK.
Carlo D L CeresaNuffield Department of Surgical Sciences, Oxford Transplant Centre, Churchill Hospital, Oxford University Hospitals, University of Oxford, Oxford, UK.
Churchill Hospital · GBInnsbruck Medical University · AT

Funding

Medical Research Council MR/P001734/1
6 · The paper itself

Abstract

Organ preservation and re-conditioning using machine perfusion technologies continue to generate promising results in terms of viability assessment, organ utilization and improved initial graft function. Here, we summarize the latest findings and study the results of ex-vivo/ex-situ hypothermic (HMP) and normothermic machine perfusion (NMP) in the area of abdominal organ transplantation (kidney, liver, pancreas and intestine). We also consider the potential role of normothermic regional perfusion (NRP) to re-condition donors after circulatory death organs before retrieval. The findings from clinical studies reported to date suggest that machine perfusion will offer real benefits when compared with conventional cold preservation. Several randomized trials are expected to report their findings within the next 2 years which may shed light on the relative merits of different perfusion methods and could indicate which perfusion parameters may be most useful to predict organ quality and viability. Further work is needed to identify composite endpoints that are relevant for transplanted organs that have undergone machine preservation. Multi-centre trials to compare and analyse the combinations of NRP followed by HMP and/or NMP, either directly after organ retrieval using transportable devices or when back-to-base, are needed. The potential applications of machine preservation technology beyond the field of solid organ transplantation are also considered.

Indexed as

Graft SurvivalAnimalsHumansIntestinesKidneyKidney TransplantationLiverLiver TransplantationOrgan PreservationPancreasPancreas TransplantationPerfusionTissue Donorshypothermicnormothermicorgan preservationregional perfusiontransplantation

Identifiers

PMID30980772
PMCPMC6850430
OpenAlexW2935810114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.