ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019
Frailty in liver transplantation: An expert opinion statement from the American Society of Transplantation Liver and Intestinal Community of Practice.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06149026 (Comparison of the Effect of Two Interventions on Liver Frailty Index in Pre-frail and Frail Cirrhotic Patients Enlisted for Liver Transplantation), which is not on this map. Cited by 119 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Effect of Two Interventions on Liver Frailty Index in Pre-frail and Frail Cirrhotic Patients Enlisted for Liver Transplantation
Who cites it
119 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- AASLD AST Practice Guideline on adult liver transplantation: Candidate evaluation.Hepatology (Baltimore, Md.) · 2026Guideline
- EASL position paper on palliative care in advanced chronic liver disease.JHEP reports : innovation in hepatology · 2026Guideline
- Malnutrition, Frailty, and Sarcopenia in Patients With Cirrhosis: 2021 Practice Guidance by the American Association for the Study of Liver Diseases.Hepatology (Baltimore, Md.) · 2021Guideline
- A Multicenter Pilot Randomized Clinical Trial of a Home-Based Exercise Program for Patients With Cirrhosis: The Strength Training Intervention (STRIVE).The American journal of gastroenterology · 2021Trial
- Home-Based Physical Activity and Diet Intervention to Improve Physical Function in Advanced Liver Disease: A Randomized Pilot Trial.Digestive diseases and sciences · 2020Trial
- Two-Step Sequential Screening for Frailty in Patients With Chronic Liver Disease: A Triage Efficiency Study of Liver Frailty Index Components.Nursing open · 2026Article
- Strength training intervention with creatine/whey protein supplementation vs placebo on frailty in older adults with cirrhosis (STRIVE): A Randomized Controlled Trial.Research square · 2026Article
- Micronutrient deficiencies in ambulatory adults with cirrhosis.Hepatology communications · 2026Article
- Physical frailty is the most important predictor of early mortality in hospitalized patients with decompensated cirrhosis.Hepatology communications · 2026Article
- Article
- Should the routine use of the 6-minute walk test be implemented in liver disease assessment: Not so fast.World journal of hepatology · 2026Article
- The Liver Transplant Comorbidity Index (LTCI): A composite index of ambulatory pre-LT factors to identify patients at increased risk of post-LT mortality.Hepatology (Baltimore, Md.) · 2026Article
- Current management strategies for sarcopenia and frailty in cirrhosis: Missing link in transplant candidacy.World journal of hepatology · 2026Review
- Pre-transplant physical performance, muscle quality, and body composition as predictors of post-liver transplant outcomes: a retrospective cohort study.European journal of medical research · 2026Article
- Evaluation of Diagnostic Tools of Sarcopenia in Chronic Liver Disease: A Cross-Sectional Observational Study.Cureus · 2026Article
- Preoperative CT-derived skeletal muscle phenotypes, postoperative complication burden, and long-term survival after liver transplantation: a 90-day landmark mediation analysis.Frontiers in nutrition · 2026Article
- Real-Life Challenges in Assessing Nutritional Status and Quality of Life in Patients with Cirrhosis.Diagnostics (Basel, Switzerland) · 2025Article
- Nutritional aspects of prehabilitation in adults with cirrhosis awaiting liver transplant.Hepatology (Baltimore, Md.) · 2025Review
- Frailty and liver transplant eligibility beyond MELD scores: integrating functional status into candidate selection.BMC gastroenterology · 2025Article
- Nationwide Analysis of Failure to Rescue After Liver Transplantation.World journal of surgery · 2025Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Frailty has emerged as a powerful predictor of outcomes in patients with cirrhosis and has inevitably made its way into decision making within liver transplantation. In an effort to harmonize integration of the concept of frailty among transplant centers, the AST and ASTS supported the efforts of our working group to develop this statement from experts in the field. Frailty is a multidimensional construct that represents the end-manifestation of derangements of multiple physiologic systems leading to decreased physiologic reserve and increased vulnerability to health stressors. In hepatology/liver transplantation, investigation of frailty has largely focused on physical frailty, which subsumes the concepts of functional performance, functional capacity, and disability. There was consensus that every liver transplant candidate should be assessed at baseline and longitudinally using a standardized frailty tool, which should guide the intensity and type of nutritional and physical therapy in individual liver transplant candidates. The working group agreed that frailty should not be used as the sole criterion for delisting a patient for liver transplantation, but rather should be considered one of many criteria when evaluating transplant candidacy and suitability. A road map to advance frailty in the clinical and research settings of liver transplantation is presented here.
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