Evidence map›Paper›PMID 30980695›Full record

ArticleJournal of magnetic resonance imaging : JMRI2019

A predictive nomogram for individualized recurrence stratification of bladder cancer using multiparametric MRI and clinical risk factors.

Xiaopan Xu, Huanjun Wang, Peng Du, Fan Zhang, Shurong Li, Zhongwei Zhang, Jing Yuan, Zhengrong Liang, Xi Zhang, Yan Guo and 2 more

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaopan XuSchool of Biomedical Engineering, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, PR China.ORCID 0000-0003-3707-1104
Huanjun WangDepartment of Radiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Peng DuSchool of Biomedical Engineering, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, PR China.
Fan ZhangDepartment of Radiology, Eastern Hospital of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, PR China.
Shurong LiDepartment of Radiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, PR China.ORCID 0000-0001-7180-9462
Zhongwei ZhangDepartment of Radiology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Jing YuanMathematics and Statistics School, Xidian University, Xi'an, Shaanxi, PR China.
Zhengrong LiangDepartments of Radiology, School of Computer Science and Biomedical Engineering, State University of New York, Stony Brook, New York, USA.
Xi ZhangSchool of Biomedical Engineering, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, PR China.ORCID 0000-0003-0032-6636
Yan GuoDepartment of Radiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Yang LiuSchool of Biomedical Engineering, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, PR China.
Hongbing LuSchool of Biomedical Engineering, Air Force Medical University (Fourth Military Medical University), Xi'an, Shaanxi, PR China.

Funding

Advancing Virtual Colonoscopy for Early Cancer ScreeningR01CA206171 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI LIANG, JEROME Z · 2016 to 2020
$2.0M
NCI NIH HHS R01 CA206171
6 · The paper itself

Abstract

backgroundPreoperative prediction of bladder cancer (BCa) recurrence risk is critical for individualized clinical management of BCa patients. PURPOSE: To develop and validate a nomogram based on radiomics and clinical predictors for personalized prediction of the first 2 years (TFTY) recurrence risk. STUDY TYPE: Retrospective. POPULATION: Preoperative MRI datasets of 71 BCa patients (34 recurrent) were collected, and divided into training (n = 50) and validation cohorts (n = 21). FIELD STRENGTH/SEQUENCE: 3.0T MRI/T ASSESSMENT: Radiomics features were extracted from the T STATISTICAL TESTS: Univariate and multivariate analyses were performed to explore the independent predictors for BCa recurrence prediction.

resultsOf the 1872 features, the 32 with the highest area under the curve (AUC) of receiver operating characteristic were selected for the Rad_Score calculation. The nomogram developed by two independent predictors, MIS and Rad_Score, showed good performance in the training (accuracy 88%, AUC 0.915, P << 0.01) and validation cohorts (accuracy 80.95%, AUC 0.838, P = 0.009). The decision curve exhibited when the risk threshold was larger than 0.3, more benefit was observed by using the radiomics-clinical nomogram than using the radiomics or clinical model alone. DATA

conclusionThe proposed radiomics-clinical nomogram has potential in the preoperative prediction of TFTY BCa recurrence. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:1893-1904.

Indexed as

NomogramsCohort StudiesHumansMultiparametric Magnetic Resonance ImagingMultivariate AnalysisNeoplasm Recurrence, LocalPredictive Value of TestsPreoperative CareRetrospective StudiesRisk FactorsUrinary Bladder Neoplasmsbladder cancermultiparametric MRInomogramrecurrence predictionSVM-RFE

Identifiers

PMID30980695
PMCPMC6790276

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.