ArticleThe New phytologist2019
Glycerol-3-phosphate acyltransferase 6 controls filamentous pathogen interactions and cell wall properties of the tomato and Nicotiana benthamiana leaf epidermis.
Article in The New phytologist, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A viral protein disrupts rice cell wall integrity and modulates interactions with viruses and insects.Stress biology · 2026Article
- Genome-wide characterization and transcriptional profiling of the glycerol-3-phosphate acyltransferase (GPAT) family in barley reveals the role of HvGPAT1 in low nitrogen tolerance.BMC plant biology · 2026Article
- Identification of 1,6-hexadecanediol and its wax diesters in chloroplasts of Nicotiana benthamiana.Planta · 2025Article
- Sugars, Lipids and More: New Insights Into Plant Carbon Sources During Plant-Microbe Interactions.Plant, cell & environment · 2025Review
- Analysis of the composition, characteristics, and antifungal properties of cutin in goji berry fruits at different developmental stages.Frontiers in plant science · 2025Article
- Genome-Wide Identification, Characterization, Evolutionary Analysis, and Expression Pattern of the GPAT Gene Family in Barley and Functional Analysis ofInternational journal of molecular sciences · 2024Article
- Beyond skin-deep: targeting the plant surface for crop improvement.Journal of experimental botany · 2023Review
- Genome-wide identification of Sclerotinia sclerotiorum small RNAs and their endogenous targets.BMC genomics · 2023Article
- Overexpression ofMetabolites · 2023Article
- Global expression patterns ofFrontiers in plant science · 2023Article
- The SlSHN2 transcription factor contributes to cuticle formation and epidermal patterning in tomato fruit.Molecular horticulture · 2022Article
- Article
- Cutin:cutin-acid endo-transacylase (CCT), a cuticle-remodelling enzyme activity in the plant epidermis.The Biochemical journal · 2021Article
- Unraveling Cuticle Formation, Structure, and Properties by Using Tomato Genetic Diversity.Frontiers in plant science · 2021Review
- An Ionic Liquid Extraction That Preserves the Molecular Structure of Cutin Shown by Nuclear Magnetic Resonance.Plant physiology · 2020Article
- Article
- Integrated Metabolomic and Transcriptomic Analysis to Characterize Cutin Biosynthesis between Low- and High-Cutin Genotypes ofInternational journal of molecular sciences · 2020Article
- N-acetyltransferase AAC(3)-I confers gentamicin resistance to Phytophthora palmivora and Phytophthora infestans.BMC microbiology · 2019Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The leaf outer epidermal cell wall acts as a barrier against pathogen attack and desiccation, and as such is covered by a cuticle, composed of waxes and the polymer cutin. Cutin monomers are formed by the transfer of fatty acids to glycerol by glycerol-3-phosphate acyltransferases, which facilitate their transport to the surface. The extent to which cutin monomers affect leaf cell wall architecture and barrier properties is not known. We report a dual functionality of pathogen-inducible GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 6 (GPAT6) in controlling pathogen entry and cell wall properties affecting dehydration in leaves. Silencing of Nicotiana benthamiana NbGPAT6a increased leaf susceptibility to infection by the oomycetes Phytophthora infestans and Phytophthora palmivora, whereas overexpression of NbGPAT6a-GFP rendered leaves more resistant. A loss-of-function mutation in tomato SlGPAT6 similarly resulted in increased susceptibility of leaves to Phytophthora infection, concomitant with changes in haustoria morphology. Modulation of GPAT6 expression altered the outer wall diameter of leaf epidermal cells. Moreover, we observed that tomato gpat6-a mutants had an impaired cell wall-cuticle continuum and fewer stomata, but showed increased water loss. This study highlights a hitherto unknown role for GPAT6-generated cutin monomers in influencing epidermal cell properties that are integral to leaf-microbe interactions and in limiting dehydration.
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