Evidence map›Paper›PMID 30980495›Full record

Observational studyHIV medicine2019

Long-term loss to follow-up in the TREAT Asia HIV Observational Database (TAHOD).

A Jiamsakul, S Kiertiburanakul, O T Ng, R Chaiwarith, W Wong, R Ditangco, K V Nguyen, A Avihingsanon, S Pujari, C D Do and 14 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in HIV medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

A JiamsakulThe Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0003-4810-0783
S KiertiburanakulFaculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
O T NgDepartment of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore.
R ChaiwarithResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
W WongTaipei Veterans General Hospital, Taipei, Taiwan.
R DitangcoResearch Institute for Tropical Medicine, Manila, Philippines.
K V NguyenNational Hospital for Tropical Diseases, Hanoi, Vietnam.
A AvihingsanonHIV-NAT, The Thai Red Cross AIDS Research Centre and Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
S PujariInstitute of Infectious Diseases, Pune, India.
C D DoBach Mai Hospital, Hanoi, Vietnam.
M-P LeeQueen Elizabeth Hospital, Hong Kong, China.
P S LyNational Center for HIV/AIDS, Dermatology & STDs, University of Health Sciences, Phnom Penh, Cambodia.
E YunihastutiWorking Group on AIDS, Faculty of Medicine, University of Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
N KumarasamyChennai Antiviral Research and Treatment Clinical Research Site (CART CRS), The Voluntary Health Services (VHS), Chennai, India.
A KamarulzamanUniversity of Malaya Medical Centre, Kuala Lumpur, Malaysia.
J TanumaNational Center for Global Health and Medicine, Tokyo, Japan.
F ZhangBeijing Ditan Hospital, Capital Medical University, Beijing, China.
J Y ChoiDivision of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
P KantipongChiangrai Prachanukroh Hospital, Chiang Rai, Thailand.
Blh SimHospital Sungai Buloh, Sungai Buloh, Malaysia.
J RossTREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
M LawThe Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.
T P MeratiFaculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia.
TREAT Asia HIV Observational Database of IeDEA Asia-Pacific

Funding

The Asia-Pacific HIV Research CollaborationU01AI069907 · NIAID · FOUNDATION FOR AIDS RESEARCH · PI ANNETTE H SOHN · 2006 to 2026
$44.8M
Australian Government Department of Health and AgeingEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute on Drug Abuse, as part of the International Epidemiology Databases to Evaluate AIDS U01AI069907NCI NIH HHSNIAID NIH HHS U01 AI069907NIMH NIH HHSNMRC Clinician Scientist Award NMRC/CSA-INV/0002/2016US National Institutes of Health's National Institute of Allergy and Infectious Diseases
6 · The paper itself

Abstract

objectivesWith earlier antiretroviral therapy (ART) initiation, time spent in HIV care is expected to increase. We aimed to investigate loss to follow-up (LTFU) in Asian patients who remained in care 5 years after ART initiation.

methodsLong-term LTFU was defined as LTFU occurring after 5 years on ART. LTFU was defined as (1) patients not seen in the previous 12 months; and (2) patients not seen in the previous 6 months. Factors associated with LTFU were analysed using competing risk regression.

resultsUnder the 12-month definition, the LTFU rate was 2.0 per 100 person-years (PY) [95% confidence interval (CI) 1.8-2.2 among 4889 patients included in the study. LTFU was associated with age > 50 years [sub-hazard ratio (SHR) 1.64; 95% CI 1.17-2.31] compared with 31-40 years, viral load ≥ 1000 copies/mL (SHR 1.86; 95% CI 1.16-2.97) compared with viral load < 1000 copies/mL, and hepatitis C coinfection (SHR 1.48; 95% CI 1.06-2.05). LTFU was less likely to occur in females, in individuals with higher CD4 counts, in those with self-reported adherence ≥ 95%, and in those living in high-income countries. The 6-month LTFU definition produced an incidence rate of 3.2 per 100 PY (95% CI 2.9-3.4 and had similar associations but with greater risks of LTFU for ART initiation in later years (2006-2009: SHR 2.38; 95% CI 1.93-2.94; and 2010-2011: SHR 4.26; 95% CI 3.17-5.73) compared with 2003-2005.

conclusionsThe long-term LTFU rate in our cohort was low, with older age being associated with LTFU. The increased risk of LTFU with later years of ART initiation in the 6-month analysis, but not the 12-month analysis, implies that there was a possible move towards longer HIV clinic scheduling in Asia.

Indexed as

Lost to Follow-UpAdultAge FactorsAntiretroviral Therapy, Highly ActiveAsiaCD4 Lymphocyte CountDrug MonitoringFemaleFollow-Up StudiesHIV InfectionsHumansIncidenceMaleRisk AssessmentAsiaHIVlong termlost to follow-up

Identifiers

PMID30980495
PMCPMC6639129

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.