ArticleAmerican journal of human biology : the official journal of the Human Biology Council2019
Regulation of inflammation during gestation and birth outcomes: Inflammatory cytokine balance predicts birth weight and length.
Article in American journal of human biology : the official journal of the Human Biology Council, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Trial
- Dietary folate, vitamin D, and inflammation modify associations between prenatal per- and polyfluoroalkyl substance (PFAS) exposures and fetal growth.Nutrition and health · 2026Article
- Associations of glyphosate and aminomethylphosphonic acid (AMPA) concentrations with birth outcomes in pregnant women from the Midwestern U.S.International journal of hygiene and environmental health · 2026Article
- Inflammatory Biomarkers and Neurotrophic Factors in Preterm Newborns as Predictors of Motor Development: A Systematic Review.Pediatric reports · 2026Review
- Adiposity-dependent adipokine-immunoglobulin interplay in mature breast milk.Frontiers in endocrinology · 2026Observational
- Well-controlled type 2 diabetes mellitus in pregnancy showed smaller fetal biometry and neonatal birth weight compared to other glycemic disorders and healthy pregnancies: a comparative cohort study.Journal of diabetes and metabolic disorders · 2025Article
- Maternal HIV Infection and Antiretroviral Therapy in Pregnancy: Implications for Vertical Transmission, Fetal Safety, and Long-Term Infant Outcomes.Pathogens (Basel, Switzerland) · 2025Review
- In Search of Environmental Factors Associated With Global Differences in Birth Weight and BMI.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Longitudinal investigation of neurobiological changes across pregnancy.Communications biology · 2025Article
- Epigenetic programming of obesity in early life through modulation of the kynurenine pathway.International journal of obesity (2005) · 2025Review
- Greenspace Morphology and Preterm Birth: A State-Wide Study in Georgia, United States (2001-2016).Environmental health perspectives · 2024Article
- Lower Socioeconomic Status Predicts Increased Proinflammatory Signaling in Late Pregnancy: Evidence From a Filipino Cohort.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Association of the humoral immune response with the inflammatory profile in Plasmodium vivax infections in pregnant women.PLoS neglected tropical diseases · 2024Observational
- Delta neutrophil index (DNI) as a potential biomarker for fetal growth restriction: insights from maternal hematological changes and neonatal outcomes.BMC pregnancy and childbirth · 2024Article
- The Negative Impact of Maternal HIV Infection on Birth Outcomes-Myth or Reality?Pathogens (Basel, Switzerland) · 2024Article
- Inflammatory imbalance in tracheal aspirate of very preterm newborns is associated with airway obstruction and lung function deficiencies at school age: a cohort study.BMJ paediatrics open · 2024Article
- The Association of Infant Birth Sizes and Anemia under Five Years Old: A Population-Based Prospective Cohort Study in China.Nutrients · 2024Article
- Association between a Mixture of Per- and Polyfluoroalkyl Substances (PFAS) and Inflammatory Biomarkers in the Atlanta African American Maternal-Child Cohort.Environmental science & technology · 2023Article
- Associations of solar activity and related exposures with fetal growth.The Science of the total environment · 2023Article
- Dynamics of inflammatory cytokine expression in bovine endometrial cells exposed to cow blood plasma small extracellular vesicles (sEV) may reflect high fertility.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
objectivesThe maternal environment during gestation influences offspring health at birth and throughout the life course. Recent research has demonstrated that endogenous immune processes such as dysregulated inflammation adversely impact birth outcomes, increasing the risk for preterm birth and restricted fetal growth. Prior analyses examining this association suggest a relationship between maternal C-reactive protein (CRP), a summary measure of inflammation, and offspring anthropometric outcomes. This study investigates pro- and anti-inflammatory cytokines, and their ratio, to gain deeper insight into the regulation of inflammation during pregnancy.
methodsIL6, IL10, TNFɑ, and CRP were quantified in dried blood spots collected in the early third trimester (mean = 29.9 weeks) of 407 pregnancies in Metropolitan Cebu, Philippines. Relationships between these immune markers and offspring anthropometrics (birth weight, length, head circumference, and sum of skinfold thicknesses) were evaluated using multivariate regression analyses. Ratios of pro- to anti-inflammatory cytokines were generated.
resultsHigher maternal IL6 relative to IL10 was associated with reduced offspring weight and length at birth. Individual cytokines did not predict birth outcomes.
conclusionsConsistent with the idea that the relative balance of cytokines with pro- and anti-inflammatory effects is a key regulator of inflammation in pregnancy, the IL6:IL10 ratio, but neither cytokine on its own, predicted offspring birth outcomes. Our findings suggest that prior reports of association between CRP and fetal growth may reflect, in part, the balance between pro- and anti-inflammatory cytokines, and that the gestational environment is significantly shaped by cytokine imbalance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.