ArticleJournal of clinical laboratory analysis2019
SNPs in LncRNA genes are associated with non-small cell lung cancer in a Chinese population.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Long Intergenic Non-Coding RNA 00511 (LINC00511) Genetic Variations and Haplotypes in Breast Cancer: A Case-Controlled Study and Bioinformatics Analysis.International journal of molecular sciences · 2025Article
- The Intergenic Type LncRNA (LINC RNA) Faces in Cancer with In Silico Scope and a Directed Lens to LINC00511: A Step toward ncRNA Precision.Non-coding RNA · 2023Review
- Association between sex hormones regulation-related SNP rs12233719 and lung cancer risk among never-smoking Chinese women.Cancer medicine · 2021Article
- LncRNA GAS5 expression in non-small cell lung cancer tissues and its correlation with Ki67 and EGFR.American journal of translational research · 2021Article
- Review
- CircRNA_103762 promotes multidrug resistance in NSCLC by targeting DNA damage inducible transcript 3 (CHOP).Journal of clinical laboratory analysis · 2020Article
- Circular RNA SMARCA5 may serve as a tumor suppressor in non-small cell lung cancer.Journal of clinical laboratory analysis · 2020Article
- LINC00152 promotes pancreatic cancer cell proliferation, migration and invasion via targeting miR-150.American journal of translational research · 2020Article
- SNPs in LncRNA genes are associated with non-small cell lung cancer in a Chinese population.Journal of clinical laboratory analysis · 2019Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIt has indicated that single nuclear polymorphisms (SNPs) in the regions encoding non-coding transcripts are associated with lung cancer susceptibility. In a previous microarray study, we identified 13 differentially expressed long non-coding RNAs (lncRNAs) in non-small cell lung cancer (NSCLC) and associations of SNPs in these lncRNA genes with lung cancer were unknown. We conducted a case-control study to address this issue.
methodsUsing the TaqMan method, we genotyped 17 SNPs located in the 13 lncRNA genes in 1294 cases with NSCLC and 1729 healthy controls. Unconditional logistic regression and Cox proportional hazards regression were used to analyze the associations of these SNPs with NSCLC risk and patient survival, respectively. These analyses were also repeated in subgroups of cases and controls stratified by gender, age group, smoking status, disease stage, and histological type.
resultsWe identified three SNPs associated with NSCLC risk. For SNP rs498238, CC genotype was associated with lower risk compared to TT genotype (adjusted OR = 0.33, 95%CI: 0.11-0.97, P = 0.043). For rs16901995, CT/TT genotypes were associated with lower risk compared to CC genotype in non-smokers (adjusted OR = 0.78, 95%CI: 0.62-0.98, P = 0.035). Variant genotypes in rs219741 were associated with NSCLC risk in young patients, and the adjusted OR was 1.47 (95%CI: 1.03-2.10, P = 0.033) when compared to the wild genotype. No SNPs were found to be associated with patient overall survival in the study.
conclusionThe study suggests that some genetic polymorphisms in the lncRNA genes may influence the risk of NSCLC among Chinese.
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