Evidence map›Paper›PMID 30980380›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

Substance P in Solution: Trans-to-Cis Configurational Changes of Penultimate Prolines Initiate Non-enzymatic Peptide Bond Cleavages.

Christopher R Conant, Daniel R Fuller, Tarick J El-Baba, Zhichao Zhang, David H Russell, David E Clemmer

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Effective discrimination of gas-phase peptide conformers using TIMS-ECD-ToF MS/MS.Analytical methods : advancing methods and applications · 2021
    Article
  7. Diketopiperazine Formation from FPGThe journal of physical chemistry. B · 2021
    Article
  8. Influence of Solvents upon Diketopiperazine Formation of FPGThe journal of physical chemistry. B · 2021
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christopher R ConantDepartment of Chemistry, Indiana University, 800 Kirkwood Avenue, Bloomington, IN, 47401, USA.
Daniel R FullerDepartment of Chemistry, Indiana University, 800 Kirkwood Avenue, Bloomington, IN, 47401, USA.
Tarick J El-BabaDepartment of Chemistry, Indiana University, 800 Kirkwood Avenue, Bloomington, IN, 47401, USA.
Zhichao ZhangDepartment of Chemistry, Indiana University, 800 Kirkwood Avenue, Bloomington, IN, 47401, USA.
David H RussellDepartment of Chemistry, Texas A&M University, College Station, TX, 77843, USA.
David E ClemmerDepartment of Chemistry, Indiana University, 800 Kirkwood Avenue, Bloomington, IN, 47401, USA. clemmer@indiana.edu.ORCID http://orcid.org/0000-0003-4039-1360
Indiana University Bloomington · USTexas A&M University · US

Funding

Development of high resolution mobility measurements for structural biologyR01GM121751 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI CLEMMER, DAVID E., LAGANOWSKY, ARTHUR D · 2017 to 2020
$1.7M
New proteome techniques: mapping adult D. MelanogasterR01GM117207 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI CLEMMER, DAVID E. · 2015 to 2018
$1.1M
National Institutes of Health P41GM121751-01A1National Institutes of Health R01 GM121751-03National Science Foundation CHE-1707675NIGMS NIH HHS R01 GM117207NIGMS NIH HHS R01 GM121751
6 · The paper itself

Abstract

We report ion mobility spectrometry and mass spectrometry studies of the non-enzymatic step-by-step degradation of substance P (subP), an 11-residue neuropeptide, with the sequence Arg

Indexed as

Amino Acid SequenceEthanolHot TemperatureHydrolysisIsomerismKineticsProlineProteolysisSubstance PThermodynamicsEthanolProlineSubstance PDissociation kineticsIon mobility spectrometry-mass spectrometryPenultimate prolinePeptide conformationProline isomerization

Identifiers

PMID30980380
PMCPMC6824264
OpenAlexW2937719283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.