ArticleActa neurochirurgica2019
Clinical outcome and prognostic factors in elderly traumatic brain injury patients receiving neurointensive care.
Article in Acta neurochirurgica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Comorbidity in traumatic brain injury and functional outcomes: a systematic review.European journal of physical and rehabilitation medicine · 2021Pooled it
- Management and outcome of patients with traumatic brain injury treated in three major Nordic intensive care units: a comparative cohort study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Observational
- Risk factors for prognosis in patients with traumatic brain injury: A retrospective observational study.Medicine · 2026Observational
- Overall outcome, functioning, and disability in older adults 3 to 14 years after traumatic brain injury.PM & R : the journal of injury, function, and rehabilitation · 2026Article
- Prognostic Significance of Preoperative Neurological Versus Radiological Deterioration in Older Patients with Moderate-to-Mild Traumatic Brain Injury.Life (Basel, Switzerland) · 2025Article
- Autoregulatory-guided management in traumatic brain injury: does age matter?Acta neurochirurgica · 2025Observational
- Cerebrovascular reactivity (PRx) and optimal cerebral perfusion pressure in elderly with traumatic brain injury.Acta neurochirurgica · 2024Article
- Early Shared Decision-Making for Older Adults with Traumatic Brain Injury: Using Time-Limited Trials and Understanding Their Limitations.Neurocritical care · 2023Article
- The effect of age on clinical outcomes in critically ill brain-injured patients.Acta neurologica Belgica · 2023Observational
- Impact of Sociodemographic, Premorbid, and Injury-Related Factors on Patient-Reported Outcome Trajectories after Traumatic Brain Injury (TBI).Journal of clinical medicine · 2023Article
- Machine Learning Algorithms to Predict In-Hospital Mortality in Patients with Traumatic Brain Injury.Journal of personalized medicine · 2021Article
- The significant impact of Coronavirus disease 2019 (COVID-19) on in-hospital mortality of elderly patients with moderate to severe traumatic brain injury: A retrospective observational study.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2021Observational
- Pre-injury antithrombotic agents predict intracranial hemorrhagic progression, but not worse clinical outcome in severe traumatic brain injury.Acta neurochirurgica · 2021Article
- Clinical predictors of prognosis in patients with traumatic brain injury combined with extracranial trauma.International journal of medical sciences · 2021Article
- Characteristics of traumatic brain injury patients with abnormal neuroimaging in Southeast Norway.Injury epidemiology · 2020Article
- Identification of Prognostic Factors in Surgically Treated Patients with Acute Epidural Hematoma.Asian journal of neurosurgeryArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe probability of favorable outcome after traumatic brain injury (TBI) decreases with age. Elderly, ≥ 60 years, are an increasing part of our population. Recent studies have shown an increase of favorable outcome in elderly over time. However, the optimal patient selection and neurointensive care (NIC) treatments may differ in the elderly and the young. The aims of this study were to examine outcome in a larger group of elderly TBI patients receiving NIC and to identify demographic and treatment related prognostic factors.
methodsPatients with TBI ≥ 60 years receiving NIC at our department between 2008 and 2014 were included. Demographics, co-morbidity, admission characteristics, and type of treatments were collected. Clinical outcome at around 6 months was assessed. Potential prognostic factors were included in univariate and multivariate regression analysis with favorable outcome as dependent variable.
resultsTwo hundred twenty patients with mean age 70 years (median 69; range 60-87) were studied. Overall, favorable outcome was 46% (Extended Glasgow Outcome Scale (GOSE) 5-8), unfavorable outcome 27% (GOSE 2-4), and mortality 27% (GOSE 1). Significant independent negative prognostic variables were high age (p < 0.05), multiple injuries (p < 0.05), GCS M ≤ 3 on admission (p < 0.05), and mechanical ventilation (p < 0.001).
conclusionsOverall, the elderly TBI patients > 60 years receiving modern NIC in this study had a fair chance of favorable outcome without large risks for severe deficits and vegetative state, also in patients over 75 years of age. High age, multiple injuries, GCS M ≤ 3 on admission, and mechanical ventilation proved to be independent negative prognostic factors. The results underline that a selected group of elderly with TBI should have access to NIC.
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