ArticleBiomechanics and modeling in mechanobiology2019
Tricuspid valve leaflet strains in the beating ovine heart.
Article in Biomechanics and modeling in mechanobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Sex-Specific Remodeling Phenotypes of the Tricuspid Valve Leaflets in an Ovine Model of Functional Tricuspid Regurgitation.bioRxiv : the preprint server for biology · 2026Article
- A Geometric Feature Tracking Approach for Noninvasive Patient-Specific Estimation of Leaflet Strain from 3D Images of Heart Valves.Annals of biomedical engineering · 2026Article
- Chordae Rupture Alters Tricuspid Valve Leaflet Biomechanics.Cardiovascular engineering and technology · 2026Article
- The In-Situ Mechanics of the Tricuspid Valve: Strain Heterogeneity and Anisotropy via 3D Digital Image Correlation.Experimental mechanics · 2026Article
- Article
- Tricuspid valve leaflet remodeling in sheep with biventricular heart failure: A comparison between leaflets.Acta biomaterialia · 2025Article
- Leaflet remodeling reduces tricuspid valve function in a computational model.Journal of the mechanical behavior of biomedical materials · 2024Article
- Force Profiles of Single Ventricle Atrioventricular Leaflets in Response to Annular Dilation and Leaflet Tethering.Seminars in thoracic and cardiovascular surgery · 2024Article
- Ex Vivo Modeling of Atrioventricular Valve Mechanics in Single Ventricle Physiology.Annals of biomedical engineering · 2023Article
- The effects of leaflet material properties on the simulated function of regurgitant mitral valves.Journal of the mechanical behavior of biomedical materials · 2023Article
- The Effects of leaflet material properties on the simulated function of regurgitant mitral valves.ArXiv · 2023Article
- Benchtop characterization of the tricuspid valve leaflet pre-strains.Acta biomaterialia · 2022Article
- Texas TriValve 1.0 : a reverse‑engineered, open model of the human tricuspid valve.Engineering with computers · 2022Article
- A Computational Framework for Atrioventricular Valve Modeling Using Open-Source Software.Journal of biomechanical engineering · 2022Article
- Three dimensional modeling of atrioventricular valves provides predictive guides for optimal choice of prosthesis.Scientific reports · 2022Article
- Tricuspid chordae tendineae mechanics: Insertion site, leaflet, and size-specific analysis and constitutive modelling.Shi yan li xue = Journal of experimental mechanics · 2021Article
- A pilot in silico modeling-based study of the pathological effects on the biomechanical function of tricuspid valves.International journal for numerical methods in biomedical engineering · 2020Article
- A Pilot Study on Linking Tissue Mechanics with Load-Dependent Collagen Microstructures in Porcine Tricuspid Valve Leaflets.Bioengineering (Basel, Switzerland) · 2020Article
- The Effect of Downsizing on the Normal Tricuspid Annulus.Annals of biomedical engineering · 2020Article
- A detailed mechanical and microstructural analysis of ovine tricuspid valve leaflets.Acta biomaterialia · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The tricuspid leaflets coapt during systole to facilitate proper valve function and, thus, ensure efficient transport of deoxygenated blood to the lungs. Between their open state and closed state, the leaflets undergo large deformations. Quantification of these deformations is important for our basic scientific understanding of tricuspid valve function and for diagnostic or prognostic purposes. To date, tricuspid valve leaflet strains have never been directly quantified in vivo. To fill this gap in our knowledge, we implanted four sonomicrometry crystals per tricuspid leaflet and six crystals along the tricuspid annulus in a total of five sheep. In the beating ovine hearts, we recorded crystal coordinates alongside hemodynamic data. Once recorded, we used a finite strain kinematic framework to compute the temporal evolutions of area strain, radial strain, and circumferential strain for each leaflet. We found that leaflet strains were larger in the anterior leaflet than the posterior and septal leaflets. Additionally, we found that radial strains were larger than circumferential strains. Area strains were as large as 97% in the anterior leaflet, 31% in the posterior leaflet, and 31% in the septal leaflet. These data suggest that tricuspid valve leaflet strains are significantly larger than those in the mitral valve. Should our findings be confirmed they could suggest either that the mechanobiological equilibrium of tricuspid valve resident cells is different than that of mitral valve resident cells or that the mechanotransductive apparatus between the two varies. Either phenomenon may have important implications for the development of tricuspid valve-specific surgical techniques and medical devices.
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