Evidence map›Paper›PMID 30980094›Full record

ArticlePsychopharmacology2019

Effects of dopaminergic and serotonergic compounds in rats trained to discriminate a high and a low training dose of the synthetic cathinone mephedrone.

Iman Saber, Andrew Milewski, Allen B Reitz, Scott M Rawls, Ellen A Walker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Iman SaberDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA, 19140, USA.
Andrew MilewskiDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA, 19140, USA.
Allen B ReitzFox Chase Chemical Diversity Center, Inc., Doylestown, PA, USA.
Scott M RawlsCenter for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Ellen A WalkerDepartment of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA, 19140, USA. ellen.walker@temple.edu.ORCID http://orcid.org/0000-0002-9323-7896

Funding

Pilot Projects Core (PPC)P30DA013429 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI Munir Gunes Kutlu · 2000 to 2026
$34.6M
Psychoactive bath salts and the glutamate systemR01DA039139 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI RAWLS, SCOTT M. · 2015 to 2019
$1.8M
Mephedrone and addiction: clues from animal modelsR21DA032718 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI RAWLS, SCOTT M. · 2012 to 2013
$337k
NIDA NIH HHS P30 DA013429NIDA NIH HHS R01 DA039139NIDA NIH HHS R21 DA032718
6 · The paper itself

Abstract

rationaleThe underlying pharmacological mechanisms of mephedrone, especially as related to interactions with different neurotransmitter systems, are a critical area of study as mephedrone continues to be abused.

objectiveDirect-acting 5-HT

methodsMale Sprague-Dawley rats were trained to discriminate either a low dose of 0.5 mg/kg mephedrone (N = 24) or a high dose of 3.2 mg/kg mephedrone (N = 11) from saline.

resultsIn the low training-dose group, mephedrone, MDMA, methamphetamine, d-amphetamine, cocaine, and enantiomers of mephedrone substituted for mephedrone; mCPP partially substituted overall for mephedrone; and DOI, WAY163909, and morphine failed to substitute for mephedrone. In the high training-dose group, only mephedrone and MDMA substituted for mephedrone. Sulpiride produced a small antagonism of the low training dose of mephedrone while SCH23390, SB242084, and ketanserin altered response rates.

conclusionsA lower training dose of mephedrone produces a discriminative stimulus fully mimicked by MDMA, methamphetamine, cocaine, and d-amphetamine, whereas a higher training dose of mephedrone requires a discriminative stimulus that was only mimicked by MDMA. Dopaminergic or serotoninergic antagonists failed to produce significant blockade of mephedrone at either training dose.

Indexed as

AlkaloidsAnimalsBenzazepinesCentral Nervous System StimulantsCocaineConditioning, OperantDextroamphetamineDiscrimination LearningDopamine AntagonistsDose-Response Relationship, DrugIllicit DrugsKetanserinMaleMethamphetaminePsychotropic DrugsRatsAlkaloidsBenzazepinescathinoneCentral Nervous System StimulantsCocaineDextroamphetamineDopamine AntagonistsIllicit DrugsKetanserinmephedroneMethamphetaminePsychotropic DrugsSCH 23390Serotonin AntagonistsDrug discriminationKetanserinMDMAMephedroneMethamphetaminePsychostimulantsRatsSB242084SCH23390Sulpiride

Identifiers

PMID30980094
PMCPMC6589396

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.