ArticleMolecular psychiatry2021
Chronic sleep fragmentation enhances habenula cholinergic neural activity.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Differential engagement of thalamic nuclei orchestrates consciousness states across anesthesia, sleep, and disorders of consciousness.Communications biology · 2025Article
- A rare variant inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Modulating the Pronociceptive Effect of Sleep Deprivation: A Possible Role for Cholinergic Neurons in the Medial Habenula.Neuroscience bulletin · 2024Article
- Sleep deprivation drives brain-wide changes in cholinergic presynapse abundance inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Specific Inhibition of Interpeduncular Nucleus GABAergic Neurons Alleviates Anxiety-Like Behaviors in Male Mice after Prolonged Abstinence from Methamphetamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Sleep-mediated regulation of reward circuits: implications in substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?Frontiers in cellular neuroscience · 2023Review
- Contingent Amygdala Inputs Trigger Heterosynaptic LTP at Hippocampus-To-Accumbens Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Gene Expression Profiling of the Habenula in Rats Exposed to Chronic Restraint Stress.Molecules and cells · 2022Article
- Interactions between Sleep and Emotions in Humans and Animal Models.Medicina (Kaunas, Lithuania) · 2022Review
- A novel cholinergic projection from the lateral parabrachial nucleus and its role in methamphetamine-primed conditioned place preference.Brain communications · 2022Article
- Development of Non-opioid Analgesics Targeting Two-pore Domain Potassium Channels.Current neuropharmacology · 2022Review
- Editorial: The Habenula and Its Role in Neuropsychiatric Symptoms.Frontiers in behavioral neuroscience · 2022Article
- Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer's disease.Frontiers in aging neuroscience · 2022Review
- Contribution of Neuronal and Glial Two-Pore-Domain Potassium Channels in Health and Neurological Disorders.Neural plasticity · 2021Review
- Bidirectional Relationship between Opioids and Disrupted Sleep: Putative Mechanisms.Molecular pharmacology · 2020Review
- TASK-3: New Target for Pain-Relief.Neuroscience bulletin · 2020Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Sleep is essential to emotional health. Sleep disturbance, particularly REM sleep disturbance, profoundly impacts emotion regulation, but the underlying neural mechanisms remain elusive. Here we show that chronic REM sleep disturbance, achieved in mice by chronic sleep fragmentation (SF), enhanced neural activity in the medial habenula (mHb), a brain region increasingly implicated in negative affect. Specifically, after a 5-day SF procedure that selectively fragmented REM sleep, cholinergic output neurons (ChNs) in the mHb exhibited increased spontaneous firing rate and enhanced firing regularity in brain slices. The SF-induced firing changes remained intact upon inhibition of glutamate, GABA, acetylcholine, and histamine receptors, suggesting cell-autonomous mechanisms independent of synaptic transmissions. Moreover, the SF-induced hyperactivity was not because of enhanced intrinsic membrane excitability, but was accompanied by depolarized resting membrane potential in mHb ChNs. Furthermore, inhibition of TASK-3 (KCNK9) channels, a subtype of two-pore domain K
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.