ArticleNature protocols2019
Nongenetic optical neuromodulation with silicon-based materials.
Article in Nature protocols, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 85 citations in OpenAlex.
- Biomimetic graphitic carbon nitride nanoparticles for multiscale photomodulation and therapeutic intervention.Nature biomedical engineering · 2026Article
- Self-Organized Nanoplasmonic Artificial Leaf for Hot-Carrier Bioelectronic Interfaces.Nature photonics · 2026Article
- Very-large-scale mimetic optogenetic synapses for physical reservoir computing.Nature communications · 2026Article
- Perspective on Nano-Enabled Photostimulation Biointerfaces.ACS nano · 2025Review
- Instant noninvasive near-infrared deep brain stimulation using optoelectronic nanoparticles without genetic modification.Science advances · 2025Article
- Nanotechnology-Fortified Manipulation of Cell CaSmall science · 2024Article
- Photothermal Excitation of Neurons Using MXene: Cellular Stress and Phototoxicity Evaluation.Advanced healthcare materials · 2024Article
- Article
- Exploring Present and Future Directions in Nano-Enhanced Optoelectronic Neuromodulation.Accounts of chemical research · 2024Review
- Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound.Nature communications · 2024Article
- Non-Faradaic optoelectrodes for safe electrical neuromodulation.Nature communications · 2024Article
- Wireless deep-brain neuromodulation using photovoltaics in the second near-infrared spectrum.Device · 2023Article
- Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities.Nature biomedical engineering · 2023Article
- Neural modulation with photothermally active nanomaterials.Nature reviews bioengineering · 2023Article
- Manipulation-specific cortical activity as mice handle food.Current biology : CB · 2022Article
- Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision.Advanced materials technologies · 2022Article
- Distributed interfacing by nanoscale photodiodes enables single-neuron light activation and sensory enhancement in 3D spinal explants.Science advances · 2022Article
- Porosity-based heterojunctions enable leadless optoelectronic modulation of tissues.Nature materials · 2022Article
- Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor.Nature biomedical engineering · 2022Article
- Engineering multiscale structural orders for high-fidelity embryoids and organoids.Cell stem cell · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Optically controlled nongenetic neuromodulation represents a promising approach for the fundamental study of neural circuits and the clinical treatment of neurological disorders. Among the existing material candidates that can transduce light energy into biologically relevant cues, silicon (Si) is particularly advantageous due to its highly tunable electrical and optical properties, ease of fabrication into multiple forms, ability to absorb a broad spectrum of light, and biocompatibility. This protocol describes a rational design principle for Si-based structures, general procedures for material synthesis and device fabrication, a universal method for evaluating material photoresponses, detailed illustrations of all instrumentation used, and demonstrations of optically controlled nongenetic modulation of cellular calcium dynamics, neuronal excitability, neurotransmitter release from mouse brain slices, and brain activity in the mouse brain in vivo using the aforementioned Si materials. The entire procedure takes ~4-8 d in the hands of an experienced graduate student, depending on the specific biological targets. We anticipate that our approach can also be adapted in the future to study other systems, such as cardiovascular tissues and microbial communities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.