ArticleScientific reports2019
The molecular genetics of hand preference revisited.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- DNA methylation in peripheral tissues and left-handedness.Scientific reports · 2022Pooled it
- Is Psychopathy a Mental Disorder or an Adaptation? Evidence From a Meta-Analysis of the Association Between Psychopathy and Handedness.Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior · 2021Pooled it
- Genome-wide association study identifies 48 common genetic variants associated with handedness.Nature human behaviour · 2021Pooled it
- Four meta-analyses across 164 studies on atypical footedness prevalence and its relation to handedness.Scientific reports · 2020Pooled it
- The genetics of situs inversus without primary ciliary dyskinesia.Scientific reports · 2020Trial
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Assessing the link among laterality, sex and competitiveness to verify the evolutionarily stable strategy of handedness.Scientific reports · 2026Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- The Balance in the Head: How Developmental Factors Explain Relationships Between Brain Asymmetries and Mental Diseases.Brain sciences · 2025Review
- Insights into the genetic architecture of cerebellar lobules derived from the UK Biobank.Scientific reports · 2024Article
- Exome-wide analysis implicates rare protein-altering variants in human handedness.Nature communications · 2024Article
- Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits.Nature human behaviour · 2024Article
- Genome-wide association and replication studies for handedness in a Korean community-based cohort.Brain and behavior · 2023Article
- Language network lateralization is reflected throughout the macroscale functional organization of cortex.Nature communications · 2023Article
- Genetic determinants of individual variation in the superior temporal sulcus of chimpanzees (Pan troglodytes).Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults.Brain structure & function · 2022Article
- Polygenic scores for handedness and their association with asymmetries in brain structure.Brain structure & function · 2022Article
- Quantitative multidimensional phenotypes improve genetic analysis of laterality traits.Translational psychiatry · 2022Article
- Broadening the scope: Increasing phenotype diversity in laterality research.Frontiers in behavioral neuroscience · 2022Article
- Mapping brain asymmetry in health and disease through the ENIGMA consortium.Human brain mapping · 2022Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hand preference is a prominent behavioural trait linked to human brain asymmetry. A handful of genetic variants have been reported to associate with hand preference or quantitative measures related to it. Most of these reports were on the basis of limited sample sizes, by current standards for genetic analysis of complex traits. Here we performed a genome-wide association analysis of hand preference in the large, population-based UK Biobank cohort (N = 331,037). We used gene-set enrichment analysis to investigate whether genes involved in visceral asymmetry are particularly relevant to hand preference, following one previous report. We found no evidence supporting any of the previously suggested variants or genes, nor that genes involved in visceral laterality have a role in hand preference. It remains possible that some of the previously reported genes or pathways are relevant to hand preference as assessed in other ways, or else are relevant within specific disorder populations. However, some or all of the earlier findings are likely to be false positives, and none of them appear relevant to hand preference as defined categorically in the general population. Our analysis did produce a small number of novel, significant associations, including one implicating the microtubule-associated gene MAP2 in handedness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.