ArticleScientific reports2019
Developmental differences in the expression of ABC transporters at rat brain barrier interfaces following chronic exposure to diallyl sulfide.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
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- Entry of cannabidiol into the fetal, postnatal and adult rat brain.Cell and tissue research · 2024Article
- The choroid plexus: a missing link in our understanding of brain development and function.Physiological reviews · 2023Review
- Bioinformatics Analysis of Exercise-Related Biomarkers in Diabetes.Genetics research · 2022Article
- Brain Distribution of Drugs: Brain Morphology, Delivery Routes, and Species Differences.Handbook of experimental pharmacology · 2022Article
- Efflux transporters in rat placenta and developing brain: transcriptomic and functional response to paracetamol.Scientific reports · 2021Article
- Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats.Fluids and barriers of the CNS · 2021Article
- ABC efflux transporters at blood-central nervous system barriers and their implications for treating spinal cord disorders.Neural regeneration research · 2020Review
- Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain.F1000Research · 2020Article
- Age- and sex-related ABC transporter expression in pyrethroid-susceptible and -resistant Aedes aegypti.Scientific reports · 2019Article
- Determinants of drug entry into the developing brain.F1000Research · 2019Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many pregnant women and prematurely born infants require medication for clinical conditions including cancer, cardiac defects and psychiatric disorders. In adults drug transfer from blood into brain is mostly restricted by efflux mechanisms (ATP-binding cassette, ABC transporters). These mechanisms have been little studied during brain development. Here expression of eight ABC transporters (abcb1a, abcb1b, abcg2, abcc1, abcc2, abcc3, abcc4, abcc5) and activity of conjugating enzyme glutathione-s-transferase (GST) were measured in livers, brain cortices (blood-brain-barrier) and choroid plexuses (blood-cerebrospinal fluid, CSF, barrier) during postnatal rat development. Controls were compared to animals chronically injected (4 days, 200 mg/kg/day) with known abcb1a inducer diallyl sulfide (DAS). Results reveal both tissue- and age-dependent regulation. In liver abcb1a and abcc3 were up-regulated at all ages. In cortex abcb1a/b, abcg2 and abcc4/abcc5 were up-regulated in adults only, while in choroid plexus abcb1a and abcc2 were up-regulated only at P14. DAS treatment increased GST activity in livers, but not in cortex or choroid plexuses. Immunocytochemistry of ABC transporters at the CSF-brain interface showed that PGP and BCRP predominated in neuroepithelium while MRP2/4/5 were prominent in adult ependyma. These results indicate an age-related capacity of brain barriers to dynamically regulate their defence mechanisms when chronically challenged by xenobiotic compounds.
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