ArticleNature communications2019
Nanomechanical DNA resonators for sensing and structural analysis of DNA-ligand complexes.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 26 citations in OpenAlex.
- TMPyP binding evokes a complex, tunable nanomechanical response in DNA.Nucleic acids research · 2024Article
- A Precise Closed-Loop Controlled ZnO Nanowire Resonator Operating at Room Temperature.Micromachines · 2022Article
- Micro/Nanopatterned Superhydrophobic Surfaces Fabrication for Biomolecules and Biomaterials Manipulation and Analysis.Micromachines · 2021Review
- Reaching silicon-based NEMS performances with 3D printed nanomechanical resonators.Nature communications · 2021Article
- DNA Studies: Latest Spectroscopic and Structural Approaches.Micromachines · 2021Review
- DNA Origami as Emerging Technology for the Engineering of Fluorescent and Plasmonic-Based Biosensors.Materials (Basel, Switzerland) · 2020Review
- Large-scale parallelization of nanomechanical mass spectrometry with weakly-coupled resonators.Nature communications · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of direct or indirect binding of intercalant molecules on DNA structure is of fundamental importance in understanding the biological functioning of DNA. Here we report on self-suspended DNA nanobundles as ultrasensitive nanomechanical resonators for structural studies of DNA-ligand complexes. Such vibrating nanostructures represent the smallest mechanical resonator entirely composed of DNA. A correlative analysis between the mechanical and structural properties is exploited to study the intrinsic changes of double strand DNA, when interacting with different intercalant molecules (YOYO-1 and GelRed) and a chemotherapeutic drug (Cisplatin), at different concentrations. Possible implications of our findings are related to the study of interaction mechanism of a wide category of molecules with DNA, and to further applications in medicine, such as optimal titration of chemotherapeutic drugs and environmental studies for the detection of heavy metals in human serum.
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Registered trials
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