Evidence map›Paper›PMID 30979871›Full record

ArticleNature communications2019

Oscillatory cortical forces promote three dimensional cell intercalations that shape the murine mandibular arch.

Hirotaka Tao, Min Zhu, Kimberly Lau, Owen K W Whitley, Mohammad Samani, Xiao Xiao, Xiao Xiao Chen, Noah A Hahn, Weifan Liu, Megan Valencia and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
  2. Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Three-dimensional cellular dynamics and mandibular morphogenesis.Frontiers in cell and developmental biology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. A thermodynamic perspective on mammalian neural crest ingression.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Measurement of adhesion and traction of cells at high yield reveals an energetic ratchet operating during nephron condensation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 6 institutions in 2 countries.

Hirotaka TaoProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Min ZhuProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Kimberly LauProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Owen K W WhitleyProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Mohammad SamaniProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Xiao XiaoProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Xiao Xiao ChenProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Noah A HahnProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Weifan LiuProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Megan ValenciaDepartment of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Min WuDepartment of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Xian WangDepartment of Mechanical and Industrial Engineering and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G8, Canada.ORCID http://orcid.org/0000-0002-1501-2544
Kelli D FenelonProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Clarissa C PasiliaoProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Di HuProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Jinchun WuProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.
Shoshana SpringMouse Imaging Centre, Hospital for Sick Children, Department of Medical Biophysics, University of Toronto, Toronto, ON, M5T 3H7, Canada.
James FergusonDepartment of Biology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Edith P KarunaDepartment of Cell Biology and Human Anatomy, University of California, Davis School of Medicine, Davis, CA, 95616, USA.
R Mark HenkelmanMouse Imaging Centre, Hospital for Sick Children, Department of Medical Biophysics, University of Toronto, Toronto, ON, M5T 3H7, Canada.
Alexander DunnDepartment of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.
Huaxiong HuangDepartment of Mathematics and Statistics, York University, Toronto, ON, M3P 1P3, Canada.
Hsin-Yi Henry HoDepartment of Cell Biology and Human Anatomy, University of California, Davis School of Medicine, Davis, CA, 95616, USA.
Radhika AtitDepartment of Biology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Sidhartha GoyalDepartment of Physics, University of Toronto, Toronto, ON, M5S 1A7, Canada.
Yu SunDepartment of Mechanical and Industrial Engineering and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G8, Canada. sun@mie.utoronto.ca.
Sevan HopyanProgram in Developmental and Stem Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada. sevan.hopyan@sickkids.ca.
University of Toronto · CAHospital for Sick Children · CACase Western Reserve University · USUniversity of California, Davis · USStanford University · USYork University · CA

Funding

Genetic mechanisms of craniofacial dermal developmentR01DE018470 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI ATIT, RADHIKA P · 2007 to 2018
$3.5M
Deciphering Wnt-Ror signaling in cytoskeletal regulation and tissue shape controlR35GM119574 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HO, HSIN-YI HENRY · 2016 to 2021
$2.0M
NIDCR NIH HHS R01 DE018470NIGMS NIH HHS R35 GM119574
6 · The paper itself

Abstract

Multiple vertebrate embryonic structures such as organ primordia are composed of confluent cells. Although mechanisms that shape tissue sheets are increasingly understood, those which shape a volume of cells remain obscure. Here we show that 3D mesenchymal cell intercalations are essential to shape the mandibular arch of the mouse embryo. Using a genetically encoded vinculin tension sensor that we knock-in to the mouse genome, we show that cortical force oscillations promote these intercalations. Genetic loss- and gain-of-function approaches show that Wnt5a functions as a spatial cue to coordinate cell polarity and cytoskeletal oscillation. These processes diminish tissue rigidity and help cells to overcome the energy barrier to intercalation. YAP/TAZ and PIEZO1 serve as downstream effectors of Wnt5a-mediated actomyosin polarity and cytosolic calcium transients that orient and drive mesenchymal cell intercalations. These findings advance our understanding of how developmental pathways regulate biophysical properties and forces to shape a solid organ primordium.

Indexed as

Cell PolarityActin CytoskeletonActomyosinAnimalsCalciumCell CycleCytoskeletonCytosolElasticityEpithelial CellsGreen Fluorescent ProteinsMandibleMiceMutationOscillometrySignal TransductionActomyosinCalciumGreen Fluorescent ProteinsVinculinWnt-5a ProteinWnt5a protein, mouse

Identifiers

PMID30979871
PMCPMC6461694
OpenAlexW2937102226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.