ArticleNature communications2019
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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58citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
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Corrections and comments
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Authors and funding
27 authors at 6 institutions in 3 countries.
Yongjie YangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Agatha A van der KlaauwUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Liangru ZhuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Tessa M CacciottoloUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0002-6646-5498
Yanlin HeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-5471-9016
Lukas K J StadlerUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Chunmei WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Pingwen XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Kenji SaitoChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Antentor HintonChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Xiaofeng YanChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Julia M KeoghUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Elana HenningUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Matthew C BantonUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Audrey E HendricksWellcome Sanger Institute, Cambridge, CB10 1SA, UK.
Elena G BochukovaUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Vanisha MistryUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
Katherine L LawlerUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-4188-1804
Lan LiaoDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Jianming XuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Stephen O'RahillyUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0003-2199-4449
Qingchun TongBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-4561-2540
UK10K Consortium
Inês BarrosoWellcome Sanger Institute, Cambridge, CB10 1SA, UK.ORCID http://orcid.org/0000-0001-5800-4520
Bert W O'MalleyDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0003-3332-1399
I Sadaf FarooqiUniversity of Cambridge Metabolic Research Laboratories, and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK. isf20@cam.ac.uk.ORCID http://orcid.org/0000-0001-7609-3504
Yong XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA. yongx@bcm.edu.ORCID http://orcid.org/0000-0002-4908-1572
University of Cambridge · GBChildren's Nutrition Research Center at Baylor College of Medicine · USBaylor College of Medicine · USWellcome Sanger Institute · GBBrown Foundation · USWuhan Union Hospital · CN
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MTISSUE COACTIVATOR AND RECEPTOR EXPRESSION FINGERPRINTSP01DK059820 · NIDDK · INSTITUT DE GENETIQUE ET BIOLOGIE MOLECU · PI MOORE, DAVID D · 2001 to 2016
$23.1MSEX HORMONE RECEPTOR COMPONENTS AND THE CELL GENOMER01HD007857 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVID M LONARD, JOHN P LYDON · 1985 to 2026
$14.6MProject 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythmsP01DK113954 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI O'MALLEY, BERT W · 2018 to 2022
$7.9MThe Role of SRC-1 in Breast CancerR01CA112403 · NCI · BAYLOR COLLEGE OF MEDICINE · PI XU, JIANMING · 2006 to 2016
$2.9MNCOA6, A Novel Tumor Suppressor of Endometrial CancerR01CA193455 · NCI · BAYLOR COLLEGE OF MEDICINE · PI XU, JIANMING · 2016 to 2021
$1.9MNeurobiology for the sex differences in energy balanceR01DK117281 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2018 to 2022
$1.8MCNS Circuits Mediating Estrogenic Regulation on Energy and Glucose HomeostasisR01DK093587 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2011 to 2015
$1.6MA direct LH to PVH projection for antagonistic regulation of feedingR01DK114279 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2018 to 2021
$1.5MTargeting hypothalamic steroid receptor co-activator-1 to treat obesityR01DK101379 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2014 to 2017
$1.2MMedial amygdala ERα neurocircuits in the regulation of physical activityR00DK107008 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XU, PINGWEN · 2018 to 2020
$743kMedial amygdala ERα neurocircuits in the regulation of physical activityK99DK107008 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, PINGWEN · 2016 to 2017
$178kBritish Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MC_UU_00014/1Medical Research Council MC_UU_12012/1NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA112403NCI NIH HHS R01 CA193455NICHD NIH HHS R01 HD007857NIDDK NIH HHS K99 DK107008NIDDK NIH HHS P01 DK059820NIDDK NIH HHS P01 DK113954NIDDK NIH HHS R00 DK107008NIDDK NIH HHS R01 DK093587NIDDK NIH HHS R01 DK101379NIDDK NIH HHS R01 DK114279NIDDK NIH HHS R01 DK117281Wellcome Trust
Abstract
Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants in SRC-1 found in severely obese individuals impair leptin-mediated Pomc reporter activity in cells, whilst four variants found in non-obese controls do not. In a knock-in mouse model of a loss of function human variant (SRC-1
Indexed as
AllelesAnimalsBody WeightCell Line, TumorCrosses, GeneticGene DeletionGene Knock-In TechniquesGenetic VariationHEK293 CellsHeterozygoteHomeostasisHumansHypothalamusLeptinMaleMembrane PotentialsLeptinNCOA1 protein, humanNcoa1 protein, mouseNuclear Receptor Coactivator 1
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