ArticleProceedings of the National Academy of Sciences of the United States of America2019
Reduced default mode network functional connectivity in patients with recurrent major depressive disorder.
2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 407 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
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407citing papers in PubMed, 7 pooled it
37.1field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) Combined With Stable Medication in Adolescents With Depression: A Randomized, Double-Blind, Controlled Pilot Study
Efficacy and Safety of Transcranial Alternating Current Stimulation (tACS) in Adolescents With First-episode Depression Who Are Drug-naive: A Randomized, Double-blind, Controlled Pilot Study
Who cites it
407 citing papers in PubMed, 7 syntheses or guidelines pooled it, 818 citations in OpenAlex.
- Neurobiological effects of microbial treatments within psychiatry: a systematic review.Frontiers in psychiatry · 2026Pooled it
- The habenula in mood disorders: A systematic review of human studies.Molecular psychiatry · 2025Pooled it
- Catalyst for change: Psilocybin's antidepressant mechanisms-A systematic review.Journal of psychopharmacology (Oxford, England) · 2025Pooled it
- Predicting the treatment outcomes of major depressive disorder interventions with baseline resting-state functional connectivity: a meta-analysis.BMC psychiatry · 2025Pooled it
- Resting-state network alterations in depression: a comprehensive meta-analysis of functional connectivity.Psychological medicine · 2025Pooled it
- Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review.Frontiers in human neuroscience · 2025Pooled it
- Neuroimaging studies of acupuncture for depressive disorder: a systematic review of published papers from 2014 to 2024.Frontiers in psychiatry · 2025Pooled it
- Comparative effects of 10-Hz rTMS and iTBS on cortico-striatal connectivity in major depressive disorder: a sham-controlled study.Molecular psychiatry · 2025Trial
- Functional Connectivity Changes Associated With Depression in Dementia With Lewy Bodies.International journal of geriatric psychiatry · 2025Trial
- Vortioxetine Improves Brain Glymphatic System Function, Functional Connectivity, and Cognitive Functions in Major Depressive Disorder.Depression and anxiety · 2025Trial
- Stable depression subtypes identified using functional connectome normative deviation models and their response to rTMS.Molecular psychiatry · 2026Article
- Depression: higher temporal variability of the functional connectivity of the ventromedial prefrontal cortex and hippocampal system.NeuroImage. Clinical · 2026Article
- Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.Molecular psychiatry · 2026Article
- Dorsolateral Prefrontal rTMS Symptom Cluster Response Trajectories for Depression.JAMA network open · 2026Observational
- Universum Inspired Graph Contrast Learning for Major Depressive Disorder Identification: In Functional Brain Network View.CNS neuroscience & therapeutics · 2026Article
- Major Depressive Disorder and Serum Inflammatory Biomarkers as Predictors of Reward-Processing Dysfunction in an American Indian Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- BriGHT: transcriptome-regularized multimodal neuroimaging for brain disorder prediction.Bioinformatics (Oxford, England) · 2026Article
- HDGNN-Mamba2: Mamba-Based Spatiotemporal Heterogeneous Dynamic Graph Neural Network for Major Depressive Disorder Classification.Brain sciences · 2026Article
- Association of Left Angular Gyrus-Right Middle Frontal Gyrus Functional Connectivity With Insomnia Severity in Major Depressive Disorder: Evidence From the DIRECT Consortium.CNS neuroscience & therapeutics · 2026Article
- From brain networks to peripheral signatures: candidate biomarkers for major depressive disorder.Translational psychiatry · 2026Article
347 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
65 authors at 20 institutions in 2 countries.
Chao-Gan YanKey Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; ycg.yan@gmail.com zhaojingping@csu.edu.cn zangyf@hznu.edu.cn.
Xiao ChenKey Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
Le LiKey Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
Francisco Xavier CastellanosDepartment of Child and Adolescent Psychiatry, New York University School of Medicine, New York, NY 10016.
Tong-Jian BaiAnhui Medical University, Hefei, Anhui 230022, China.
Qi-Jing BoBeijing Anding Hospital, Capital Medical University, Beijing 100054, China.
Jun CaoDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Guan-Mao ChenThe First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
Ning-Xuan ChenKey Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
Wei ChenDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.
Chang ChengDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Yu-Qi ChengFirst Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Xi-Long CuiDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Jia DuanDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China.
Yi-Ru FangDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Qi-Yong GongDepartment of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Wen-Bin GuoDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Zheng-Hua HouDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210096, China.
Lan HuDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Li KuangDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Feng LiBeijing Anding Hospital, Capital Medical University, Beijing 100054, China.
Kai-Ming LiDepartment of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Tao LiMental Health Center, West China Hospital, Sichuan University Chengdu, Sichuan 610041, China.
Yan-Song LiuDepartment of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu 215137, China.
Zhe-Ning LiuDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Yi-Cheng LongDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Qing-Hua LuoDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Hua-Qing MengDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Dai-Hui PengDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Hai-Tang QiuDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Jiang QiuFaculty of Psychology, Southwest University, Chongqing 400716, China.
Yue-Di ShenDepartment of Diagnostics, Affiliated Hospital, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
Yu-Shu ShiDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Chuan-Yue WangBeijing Anding Hospital, Capital Medical University, Beijing 100054, China.ORCID 0000-0001-6549-3713
Fei WangDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China.
Kai WangAnhui Medical University, Hefei, Anhui 230022, China.
Li WangNational Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China.
Xiang WangDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Ying WangThe First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
Xiao-Ping WuXi'an Central Hospital, Xi'an, Shaanxi 710003, China.
Xin-Ran WuFaculty of Psychology, Southwest University, Chongqing 400716, China.
Chun-Ming XieDepartment of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu 210009, China.
Guang-Rong XieDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Hai-Yan XieDepartment of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Peng XieInstitute of Neuroscience, Chongqing Medical University, Chongqing 400016, China.
Xiu-Feng XuFirst Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Hong YangDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Jian YangThe First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi 710061, China.
Jia-Shu YaoDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.
Shu-Qiao YaoDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Ying-Ying YinDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210096, China.
Yong-Gui YuanDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210096, China.
Ai-Xia ZhangThe First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi 710061, China.
Hong ZhangXi'an Central Hospital, Xi'an, Shaanxi 710003, China.
Ke-Rang ZhangFirst Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Lei ZhangKey Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
Zhi-Jun ZhangDepartment of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu 210009, China.
Ru-Bai ZhouDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Yi-Ting ZhouMental Health Center, West China Hospital, Sichuan University Chengdu, Sichuan 610041, China.
Jun-Juan ZhuDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Chao-Jie ZouFirst Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Tian-Mei SiNational Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China.
Xi-Nian ZuoKey Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0001-9110-585X
Jing-Ping ZhaoDepartment of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; ycg.yan@gmail.com zhaojingping@csu.edu.cn zangyf@hznu.edu.cn.
Yu-Feng ZangCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; ycg.yan@gmail.com zhaojingping@csu.edu.cn zangyf@hznu.edu.cn.ORCID 0000-0003-1833-8010
Central South University · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CNZhongda Hospital Southeast University · CNInstitute of Psychology, Chinese Academy of Sciences · CNShanghai Jiao Tong University · CNCapital Medical University · CNKunming Medical University · CNSichuan University · CNSouthwest University · CNAnhui Medical University · CNChinese Academy of Sciences · CNFirst Affiliated Hospital of Jinan University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNFirst Hospital of China Medical University · CNPeking University · CNSir Run Run Shaw Hospital · CNZhejiang University · CNAffiliated Hospital of Hangzhou Normal University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHangzhou Normal University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power and data analysis approaches have varied widely. The REST-meta-MDD Project of resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups in China established the REST-meta-MDD Consortium by contributing R-fMRI data from 1,300 patients with MDD and 1,128 normal controls (NCs). Data were preprocessed locally with a standardized protocol before aggregated group analyses. We focused on functional connectivity (FC) within the default mode network (DMN), frequently reported to be increased in MDD. Instead, we found decreased DMN FC when we compared 848 patients with MDD to 794 NCs from 17 sites after data exclusion. We found FC reduction only in recurrent MDD, not in first-episode drug-naïve MDD. Decreased DMN FC was associated with medication usage but not with MDD duration. DMN FC was also positively related to symptom severity but only in recurrent MDD. Exploratory analyses also revealed alterations in FC of visual, sensory-motor, and dorsal attention networks in MDD. We confirmed the key role of DMN in MDD but found reduced rather than increased FC within the DMN. Future studies should test whether decreased DMN FC mediates response to treatment. All R-fMRI indices of data contributed by the REST-meta-MDD consortium are being shared publicly via the R-fMRI Maps Project.
Indexed as
BrainBrain MappingChinaConnectomeFemaleHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleNeural PathwaysRestdefault mode networkfunctional connectivitymajor depressive disorderresting-state fMRIREST-meta-MDD
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT07185451ClinicalTrials.gov
NCT07185464ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.