Evidence map›Paper›PMID 30979708›Full record

ArticleEMBO reports2019

An alternatively transcribed

Chuantao Fang, Jian Li, Sixian Qi, Yubin Lei, Yan Zeng, Pengcheng Yu, Zhaolan Hu, Yufeng Zhou, Yulong Wang, Ruping Dai and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Identification of AMOTL2 as an antiviral factor that enhances the human type I interferon response against Zika virus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Chuantao FangChildren's Hospital and Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China.
Jian LiChildren's Hospital and Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China.
Sixian QiChildren's Hospital and Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China.
Yubin LeiChildren's Hospital and Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China.
Yan ZengChildren's Hospital and Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China.
Pengcheng YuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Zhaolan HuDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Yufeng ZhouChildren's Hospital and Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China.
Yulong WangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Ruping DaiDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Jin LiChildren's Hospital and Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China.
Shenglin HuangFudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Pinglong XuLife Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, China.ORCID 0000-0001-7726-5443
Kang ChenPerinatology Research Branch, Eunice Kennedy Shriver NICHD, National Institutes of Health, Detroit, MI, USA.
Chen DingState Key Laboratory of Genetic Engineering, Human Phenome Institute, Institutes of Biomedical Sciences, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.
Fa-Xing YuChildren's Hospital and Institutes of Biomedical Sciences, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China fxyu@fudan.edu.cn.
Children's Hospital of Fudan University · CNCentral South University · CNShanghai Medical College of Fudan University · CNFudan University · CNFudan University Shanghai Cancer Center · CNNational Institutes of Health · USZhejiang University · CN

Funding

Understanding and harnessing the functions of B cells to prevent preterm laborR21AI138089 · NIAID · WAYNE STATE UNIVERSITY · PI CHEN, KANG · 2019 to 2020
$424k
Mechanism of Humoral Immune Defects in Autoimmune Polyglandular Syndrome Type 1R21AI122256 · NIAID · WAYNE STATE UNIVERSITY · PI CHEN, KANG · 2016 to 2017
$419k
6 · The paper itself

Abstract

Type I interferon (IFN)-induced Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling drives the expression of IFN-stimulated genes (ISGs) to mediate antiviral response. The strength and duration of JAK-STAT signaling are tightly regulated to ensure effective antiviral defense while avoiding pathological inflammation and autoimmunity. Here, we report that cTAZ, an isoform of the Hippo pathway effector TAZ, is transcribed by an alternative promoter. Although majority of C-terminal sequences of TAZ is retained, cTAZ is not regulated by the Hippo signaling and does not mediate its growth-inhibitory functions. Instead, cTAZ negatively regulates JAK-STAT signaling by inhibiting STAT1/2 nuclear localization and ISG expression, and its expression is induced by type I IFN Thus, cTAZ functions as a modulator of JAK-STAT signaling and may play a role in fine-tuning cellular antiviral response.

Indexed as

Promoter Regions, GeneticSignal TransductionTranscription, GeneticAnimalsGene Expression ProfilingHippo Signaling PathwayHumansJanus KinasesMiceModels, BiologicalPhosphorylationProtein BindingProtein MultimerizationProtein Serine-Threonine KinasesProtein TransportRNA IsoformsJanus KinasesProtein Serine-Threonine KinasesRNA IsoformsSTAT Transcription FactorsTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsWWTR1 protein, humanalternative transcriptHippo pathwayJAK‐STAT pathwayviral infection

Identifiers

PMID30979708
PMCPMC6549033
OpenAlexW2936731687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.