ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Reduced Amygdala-Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04654260 (Behavior Therapy for Irritability and Aggression in Adolescents With Autism), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Behavior Therapy for Irritability and Aggression in Adolescents With Autism
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- The relationship between psychopathy and autism: a systematic review and narrative synthesis.Frontiers in psychiatry · 2024Pooled it
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- Transcranial Direct Current Stimulation (tDCS) over the Left Dorsal Lateral Prefrontal Cortex in Children with Autism Spectrum Disorder (ASD).Neural plasticity · 2021Trial
- Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026Review
- Meeting the Needs of Neurodivergent Teens for Dialectical Behaviour Therapy: Challenges and Adaptation Strategies From Clinicians, Teens With Fetal Alcohol Spectrum Disorders and Caregivers.Journal of applied research in intellectual disabilities : JARID · 2026Article
- Sensory and Executive Function Subtypes Associated With Participation in Adolescents With Autism Spectrum Disorder: A Latent Profile Analysis Approach.Journal of autism and developmental disorders · 2026Article
- Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth.Biological psychiatry global open science · 2026Article
- Prenatal Cannabis Exposure Shaping Altered Brain Connectivity: Neural Correlates of Cognitive and Mental Health Variability in Offspring.Research square · 2026Article
- Connections Between Prefrontal Cortex Anatomy and Autism Spectrum Disorder: A Literature Review.Acta medica academica · 2025Review
- Aggression and Risk Behaviors in a Group of Adolescents with High-Functioning Autism.Children (Basel, Switzerland) · 2025Article
- The dark sides of the brain: A systematic review and meta-analysis of functional neuroimaging studies on trait aggressionAggression and violent behavior · 2025Article
- Investigating the impact of lumping heterogenous conduct problems: aggression and rule-breaking rely on distinct spontaneous brain activity.European child & adolescent psychiatry · 2025Article
- Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review).Frontiers in human neuroscience · 2025Review
- Atypical neural encoding of faces in individuals with autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Neural correlates of facial recognition deficits in autism spectrum disorder: a comprehensive review.Frontiers in psychiatry · 2024Review
- Callous unemotional traits mediate the presence of challenging behaviors in adults with autism spectrum disorder and intellectual disability.International journal of developmental disabilities · 2024Article
- Functional connectivity between the amygdala and prefrontal cortex underlies processing of emotion ambiguity.Translational psychiatry · 2023Article
- Pathways to Psychopathology Among Autistic Adults.Current psychiatry reports · 2023Review
- A revisit of the amygdala theory of autism: Twenty years after.Neuropsychologia · 2023Review
- Emotional dysregulation as a part of the autism spectrum continuum: a literature review from late childhood to adulthood.Frontiers in psychiatry · 2023Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDisruptive behaviors are prevalent in children with autism spectrum disorder (ASD) and often cause substantial impairments. However, the underlying neural mechanisms of disruptive behaviors remain poorly understood in ASD. In children without ASD, disruptive behavior is associated with amygdala hyperactivity and reduced connectivity with the ventrolateral prefrontal cortex (vlPFC). This study examined amygdala reactivity and connectivity in children with ASD with and without co-occurring disruptive behavior disorders. We also investigated differential contributions of externalizing behaviors and callous-unemotional traits to variance in amygdala connectivity and reactivity.
methodsThis cross-sectional study involved behavioral assessments and neuroimaging in three groups of children 8 to 16 years of age: 18 children had ASD and disruptive behavior, 20 children had ASD without disruptive behavior, and 19 children were typically developing control participants matched for age, gender, and IQ. During functional magnetic resonance imaging, participants completed an emotion perception task of fearful versus calm faces. Task-specific changes in amygdala reactivity and connectivity were examined using whole-brain, psychophysiological interaction, and multiple regression analyses.
resultsChildren with ASD and disruptive behavior showed reduced amygdala-vlPFC connectivity compared with children with ASD without disruptive behavior. Externalizing behaviors and callous-unemotional traits were associated with amygdala reactivity to fearful faces in children with ASD after controlling for suppressor effects.
conclusionsReduced amygdala-vlPFC connectivity during fear processing may differentiate children with ASD and disruptive behavior from children with ASD without disruptive behavior. The presence of callous-unemotional traits may have implications for identifying differential patterns of amygdala activity associated with increased risk of aggression in ASD. These findings suggest a neural mechanism of emotion dysregulation associated with disruptive behavior in children with ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.