Evidence map›Paper›PMID 30979435›Full record

ArticleNeurobiology of aging2019

Identification of genetic heterogeneity of Alzheimer's disease across age.

Min-Tzu Lo, Karolina Kauppi, Chun-Chieh Fan, Nilotpal Sanyal, Emilie T Reas, V S Sundar, Wen-Chung Lee, Rahul S Desikan, Linda K McEvoy, Chi-Hua Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Article
  5. Article
  6. Dissecting Alzheimer's disease heritability across populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Risk of Alzheimer's disease in Down syndrome: Insights gained by multi-omics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Towards cascading genetic risk in Alzheimer's disease.Brain : a journal of neurology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Min-Tzu LoCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, CA, USA; Department of Bioinformatics, Ambry Genetics, Aliso Viejo, CA, USA. Electronic address: lomintzu@gmail.com.
Karolina KauppiCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, CA, USA; Department of Radiation Sciences, Umea University, Umea, Sweden.
Chun-Chieh FanCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, CA, USA; Department of Cognitive Science, University of California, San Diego, CA, USA.
Nilotpal SanyalCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, CA, USA.
Emilie T ReasCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, CA, USA.
V S SundarCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, CA, USA.
Wen-Chung LeeDepartment of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Rahul S DesikanNeuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Linda K McEvoyCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, CA, USA.
Chi-Hua ChenCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, CA, USA. Electronic address: chc101@ucsd.edu.
Alzheimer's Disease Genetics Consortium

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
Genetic architecture of the human brain and neuropsychiatric disordersR01MH118281 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, CHI-HUA · 2019 to 2023
$2.7M
Identifying the Polygenic Basis of the Human Brain and Psychiatric DisordersR01MH100351 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, CHI-HUA · 2013 to 2017
$2.1M
Omic analyses for stratifying Alzheimer's subtypes and identifying novel drug targetsR56AG061163 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, CHI-HUA · 2018 to 2018
$560k
NIA NIH HHS R56 AG061163NIA NIH HHS U01 AG032984NIA NIH HHS U24 AG021886NIMH NIH HHS R01 MH100351NIMH NIH HHS R01 MH118281
6 · The paper itself

Abstract

The risk of APOE for Alzheimer's disease (AD) is modified by age. Beyond APOE, the polygenic architecture may also be heterogeneous across age. We aim to investigate age-related genetic heterogeneity of AD and identify genomic loci with differential effects across age. Stratified gene-based genome-wide association studies and polygenic variation analyses were performed in the younger (60-79 years, N = 14,895) and older (≥80 years, N = 6559) age-at-onset groups using Alzheimer's Disease Genetics Consortium data. We showed a moderate genetic correlation (r

Indexed as

Genetic HeterogeneityAlzheimer DiseaseHumansAlzheimer's diseaseGene-based analysisGenetic correlationGenetic heterogeneityStratified GWAS

Identifiers

PMID30979435
PMCPMC6783343

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.