ReviewPolymers2016
Polymers in Cartilage Defect Repair of the Knee: Current Status and Future Prospects.
Review in Polymers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- Autologous Chondrocyte Implantation on Polyethersulfone Scaffolds in a Rabbit Model of Grade III Lesions.Molecules (Basel, Switzerland) · 2026Article
- Precision theranostics in cervical Cancer: Harnessing stimuli-responsive hydrogels for tumor microenvironment-targeted therapy and diagnosis.Materials today. Bio · 2025Review
- Evaluation of cartilage regeneration using a hybrid bilayer scaffold based on omentum: evidence of limited efficacy.Journal of orthopaedic surgery and research · 2025Article
- Design and Evaluation of a Crosslinked Chitosan-Based Scaffold Containing Hyaluronic Acid for Articular Cartilage Reconstruction.Molecules (Basel, Switzerland) · 2025Article
- Comparative Study of Autogenic and Allogenic Chondrocyte Transplants on Polyethersulfone Scaffolds for Cartilage Regeneration.International journal of molecular sciences · 2024Article
- Enhanced hyaline cartilage formation and continuous osteochondral regeneration via 3D-Printed heterogeneous hydrogel with multi-crosslinking inks.Materials today. Bio · 2024Article
- Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinicalRoyal Society open science · 2024Article
- Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) reveals potential lipid markers between infrapatellar fat pad biopsies of osteoarthritis and cartilage defect patients.Analytical and bioanalytical chemistry · 2023Article
- Cartilage repair strategies in the knee according to Dutch Orthopedic Surgeons: a survey study.Archives of orthopaedic and trauma surgery · 2023Article
- Article
- Advanced Polymeric Membranes as Biomaterials Based on Marine Sources Envisaging the Regeneration of Human Tissues.Gels (Basel, Switzerland) · 2023Article
- Article
- Recent Developments and Current Applications of Hydrogels in Osteoarthritis.Bioengineering (Basel, Switzerland) · 2022Review
- 3D printed porous sulfonated polyetheretherketone scaffold for cartilage repair: Potential and limitation.Journal of orthopaedic translation · 2022Article
- Article
- The Emerging Use of ASC/Scaffold Composites for the Regeneration of Osteochondral Defects.Frontiers in bioengineering and biotechnology · 2022Review
- Therapeutic application of hydrogels for bone-related diseases.Frontiers in bioengineering and biotechnology · 2022Review
- Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges.Bioactive materials · 2021Review
- Jellyfish Collagen: A Biocompatible Collagen Source for 3D Scaffold Fabrication and Enhanced Chondrogenicity.Marine drugs · 2021Article
- Current hip cartilage regeneration/repair modalities: a scoping review of biologics and surgery.International orthopaedics · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cartilage defects in the knee are often seen in young and active patients. There is a need for effective joint preserving treatments in patients suffering from cartilage defects, as untreated defects often lead to osteoarthritis. Within the last two decades, tissue engineering based techniques using a wide variety of polymers, cell sources, and signaling molecules have been evaluated. We start this review with basic background information on cartilage structure, its intrinsic repair, and an overview of the cartilage repair treatments from a historical perspective. Next, we thoroughly discuss polymer construct components and their current use in commercially available constructs. Finally, we provide an in-depth discussion about construct considerations such as degradation rates, cell sources, mechanical properties, joint homeostasis, and non-degradable/hybrid resurfacing techniques. As future prospects in cartilage repair, we foresee developments in three areas: first, further optimization of degradable scaffolds towards more biomimetic grafts and improved joint environment. Second, we predict that patient-specific non-degradable resurfacing implants will become increasingly applied and will provide a feasible treatment for older patients or failed regenerative treatments. Third, we foresee an increase of interest in hybrid construct, which combines degradable with non-degradable materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.