Evidence map›Paper›PMID 30979274›Full record

ArticlePolymers2016

Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy.

Ruirui Xing, Tifeng Jiao, Yamei Liu, Kai Ma, Qianli Zou, Guanghui Ma, Xuehai Yan

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 133 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ruirui XingState Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China. rrxing@ipe.ac.cn.
Tifeng JiaoState Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China. tfjiao@ysu.edu.cn.ORCID 0000-0003-1238-0277
Yamei LiuState Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China. liuym@ipe.ac.cn.
Kai MaState Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China. makai@ipe.ac.cn.
Qianli ZouNational Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. qlzou@ipe.ac.cn.
Guanghui MaNational Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. ghma@ipe.ac.cn.
Xuehai YanNational Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. yanxh@ipe.ac.cn.
Yanshan University · CNInstitute of Process Engineering · CN

Funding

national natural science foundation of China 21473153, 21522307, 21473208, 91434103 and 51403214
6 · The paper itself

Abstract

The inactivation of photosensitizers before they reach the targeted tissues can be an important factor, which limits the efficacy of photodynamic therapy (PDT). Here, we developed co-assembled nanohybrids of graphene oxide (GO) and albumin/photosensitizer that have a potential for protecting the photosensitizers from the environment and releasing them in targeted sites, allowing for an enhanced PDT. The nanohybrids were prepared by loading the pre-assembled nanoparticles of chlorin e6 (Ce6) and bovine serum albumin (BSA) on GO via non-covalent interactions. The protection to Ce6 is evident from the inhibited fluorescence and singlet oxygen generation activities of Ce6⁻BSA⁻GO nanohybrids. Importantly, compared to free Ce6 and Ce6 directly loaded by GO (Ce6⁻GO), Ce6⁻BSA⁻GO nanohybrids showed enhanced cellular uptake and

Indexed as

co-assemblygraphene oxidephotodynamic therapyproteinsinglet oxygen generation

Identifiers

PMID30979274
PMCPMC6431907
OpenAlexW2345511023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.