Evidence map›Paper›PMID 30979069›Full record

ArticleAntibiotics (Basel, Switzerland)2019

Rifampicin-Loaded Mesoporous Silica Nanoparticles for the Treatment of Intracellular Infections.

Santhni Subramaniam, Nicky Thomas, Hanna Gustafsson, Manasi Jambhrunkar, Stephen P Kidd, Clive A Prestidge

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  13. Combinatorial efficacy of Manuka honey and antibiotics in theFrontiers in cellular and infection microbiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Santhni SubramaniamSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia. santhni.subramaniam@mymail.unisa.edu.au.
Nicky ThomasSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia. nicky.thomas@unisa.edu.au.
Hanna GustafssonSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia. hanna.gustafsson@unisa.edu.au.
Manasi JambhrunkarSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia. manasi.jambhrunkar@unisa.edu.au.
Stephen P KiddResearch Centre for Infectious Disease, School of Biological Sciences, The University of Adelaide, Adelaide, SA 5000, Australia. stephen.kidd@adelaide.edu.au.
Clive A PrestidgeSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5000, Australia. clive.prestidge@unisa.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious diseases remain a major burden in today's world, causing high mortality rates and significant economic losses, with >9 million deaths per year predicted by 2030. Invasion of host cells by intracellular bacteria poses treatment challenges due to the poor permeation of antimicrobials into the infected cells. To overcome these limitations, mesoporous silica nanoparticles (MSNP) loaded with the antibiotic rifampicin were investigated as a nanocarrier system for the treatment of intracellular bacterial infection with specific interest in the influence of particle size on treatment efficiency. An intracellular infection model was established using small colony variants (SCV) of

Indexed as

antibioticsintracellular infectionsmacrophagesMSNPnanoparticlesrifampicinSCVs

Identifiers

PMID30979069
PMCPMC6628058

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.