Evidence map›Paper›PMID 30979012›Full record

ArticleInternational journal of molecular sciences2019

Altered Glutamate Receptor Ionotropic Delta Subunit 2 Expression in Stau2-Deficient Cerebellar Purkinje Cells in the Adult Brain.

Helena F Pernice, Rico Schieweck, Mehrnoosh Jafari, Tobias Straub, Martin Bilban, Michael A Kiebler, Bastian Popper

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Helena F PerniceBiomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians- University, 82152 Martinsried, Germany. Franziska.Pernice@med.uni-muenchen.de.
Rico SchieweckBiomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians- University, 82152 Martinsried, Germany. Rico.Schieweck@med.uni-muenchen.de.
Mehrnoosh JafariInstitute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-University, 81377 Munich, Germany. mehrnoosh.jafari@med.uni-muenchen.de.
Tobias StraubBiomedical Center (BMC), Core Facility Bioinformatics, Medical Faculty, Ludwig-Maximilians-University, 82152 Martinsried, Germany. tstraub@bmc.med.lmu.de.
Martin BilbanDepartment of Laboratory Medicine and Core Facility Genomics, Medical University of Vienna, 1090 Vienna, Austria. martin.bilban@meduniwien.ac.at.
Michael A KieblerBiomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians- University, 82152 Martinsried, Germany. mkiebler@lmu.de.ORCID 0000-0002-8850-6297
Bastian PopperBiomedical Center (BMC), Department for Cell Biology & Anatomy, Medical Faculty, Ludwig-Maximilians- University, 82152 Martinsried, Germany. bastian.popper@med.uni-muenchen.de.ORCID 0000-0003-1517-695X
Ludwig-Maximilians-Universität München · DEMedical University of Vienna · AT

Funding

Deutsche Forschungsgemeinschaft FOR2333Deutsche Forschungsgemeinschaft Kie 502/2-1Deutsche Forschungsgemeinschaft Kie 502/3-1Deutsche Forschungsgemeinschaft SPP1738Friedrich-Baur-Stiftung 02/14Friedrich-Baur-Stiftung 02/16
6 · The paper itself

Abstract

Staufen2 (Stau2) is an RNA-binding protein that is involved in dendritic spine morphogenesis and function. Several studies have recently investigated the role of Stau2 in the regulation of its neuronal target mRNAs, with particular focus on the hippocampus. Here, we provide evidence for Stau2 expression and function in cerebellar Purkinje cells. We show that Stau2 downregulation (Stau2

Indexed as

AgingGene Expression RegulationAnimalsBrainCerebellumFemaleGene DeletionMaleMice, Inbred C57BLMotor ActivityNerve Tissue ProteinsPurkinje CellsReceptors, GlutamateRNA-Binding ProteinsRNA, Messengerglutamate receptor delta 2Nerve Tissue ProteinsReceptors, GlutamateRNA-Binding ProteinsRNA, Messengerstau2 protein, mousecerebellumGluD2purkinje cellsstaufen2synaptogenesis

Identifiers

PMID30979012
PMCPMC6480955
OpenAlexW2935892216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.