Evidence map›Paper›PMID 30978941›Full record

ArticleSensors (Basel, Switzerland)2019

Application of a Waveguide-Mode Sensor to Blood Testing for Hepatitis B Virus, Hepatitis C Virus, Human Immunodeficiency Virus and

Shigeyuki Uno, Takenori Shimizu, Torahiko Tanaka, Hiroki Ashiba, Makoto Fujimaki, Mutsuo Tanaka, Koichi Awazu, Makoto Makishima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shigeyuki UnoDivision of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan. uno.shigeyuki@nihon-u.ac.jp.
Takenori ShimizuDivision of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan. shimizu.takenori16@gmail.com.
Torahiko TanakaDivision of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan. torahiko.tanaka@gmail.com.
Hiroki AshibaElectronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan. h.ashiba@aist.go.jp.
Makoto FujimakiElectronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan. m-fujimaki@aist.go.jp.ORCID 0000-0003-4856-422X
Mutsuo TanakaDepartment of Life Science & Green Chemistry, Saitama Institute of Technology, 1690 Fusaiji, Fukaya, Saitama 369-0293, Japan. mutsuo-tanaka@sit.ac.jp.
Koichi AwazuElectronics and Photonics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan. k.awazu@aist.go.jp.
Makoto MakishimaDivision of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan. makishima.makoto@nihon-u.ac.jp.ORCID 0000-0002-4630-905X
Nihon University · JPNational Institute of Advanced Industrial Science and Technology · JPSaitama Institute of Technology · JP

Funding

SENTAN program of Japan Science and Technology Agency (2012-2014) and Japan Agency for Medical Research and Development (2015-2016) 15hm0102001h0004 and 16hm0102001s0205
6 · The paper itself

Abstract

Testing for blood-transmitted infectious agents is an important aspect of safe medical treatment. During emergencies, such as significant earthquakes, many patients need surgical treatment and/or blood transfusion. Because a waveguide mode (WM) sensor can be used as a portable, on-site blood testing device in emergency settings, we have previously developed WM sensors for detection of antibodies against hepatitis B virus and hepatitis C virus and for forward ABO and Rh(D) and reverse ABO blood typing. In this study, we compared signal enhancement methods using secondary antibodies conjugated with peroxidase, a fluorescent dye, and gold nanoparticles, and found that the peroxidase reaction method offers superior sensitivity while gold nanoparticles provide the most rapid detection of anti-HBs antibody. Next, we examined whether we could apply a WM sensor with signal enhancement with peroxidase or gold nanoparticles to detection of antibodies against hepatitis C virus, human immunodeficiency virus and

Indexed as

Biosensing TechniquesABO Blood-Group SystemAntibodiesGoldHepacivirusHepatitis B virusHepatitis CHIVHIV InfectionsHumansMetal NanoparticlesSyphilisTreponema pallidumABO Blood-Group SystemAntibodiesGoldhepatitis B virushepatitis C virushuman immunodeficiency viruson-site blood testingTreponema pallidumwaveguide-mode sensor

Identifiers

PMID30978941
PMCPMC6479333
OpenAlexW2939419225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.