Evidence map›Paper›PMID 30978926›Full record

ReviewJournal of clinical medicine2019

Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation.

Darren G Candow, Scott C Forbes, Philip D Chilibeck, Stephen M Cornish, Jose Antonio, Richard B Kreider

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 85 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 8 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05878106 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Creatine Supplementation and Resistance Training in Patients With Breast Cancer (CaRTiC Study)

TypeinterventionalSponsorUniversity of DeustoRan2024 to 2025Enrolled120ConditionsBreast Cancer, Supplementation, Resistance Training, Physical PerformanceArmsCreatine supplementation, Resistance training
NCT06948149 narecruitingnot on this mapstarted 2026, after this paper: background citation

Examining the Effects of Creatine Supplementation and Resistance Training on Cognition and Brain Health in Older Adults With Mild Cognitive Impairment: a 26 Week Randomized Controlled Trial

TypeinterventionalSponsorWestern University, CanadaRan2026 to 2027Enrolled140ConditionsCreatine, Exercise, Mild Cognitive Impairment (MCI)ArmsCreatine monohydrate, Resistance training
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 8 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Pooled it
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  4. Understanding the gut microbiota and sarcopenia: a systematic review.Journal of cachexia, sarcopenia and muscle · 2021
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  9. Trial
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  16. Integrative Analysis Coupled with In Vitro Validation RevealsInternational journal of molecular sciences · 2026
    Article
  17. Why Osteosarcopenia Matters: Clinical and Investigative Implications.European journal of clinical investigation · 2026
    Review
  18. Article
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 2 countries.

Darren G CandowFaculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2, Canada. Darren.Candow@uregina.ca.
Scott C ForbesDepartment of Physical Education, Brandon University, Brandon, MB R7A 6A9, Canada. ForbesS@BrandonU.CA.
Philip D ChilibeckCollege of Kinesiology, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada. phil.chilibeck@usask.ca.
Stephen M CornishFaculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada. Stephen.Cornish@umanitoba.ca.
Jose AntonioDepartment of Health and Human Performance, Nova Southeastern University, Davie, FL 33314, USA. Exphys@aol.com.
Richard B KreiderDepartment of Health and Kinesiology, Texas A&M University, College Station, TX 77843-4253, USA. rbkreider@tamu.edu.ORCID 0000-0002-3906-1658
Brandon University · CANova Southeastern University · USTexas A&M University · USUniversity of Manitoba · CAUniversity of Regina · CAUniversity of Saskatchewan · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral. Therefore, the purpose of this review is to: (1) summarize the effects of creatine supplementation, with and without resistance training, in aging adults and discuss possible mechanisms of action, (2) examine the effects of creatine on bone biology and risk of falls, (3) evaluate the potential anti-inflammatory effects of creatine and (4) determine the safety of creatine supplementation in aging adults.

Indexed as

dynapeniaexercisefunctionalitymechanismssafetysarcopenia

Identifiers

PMID30978926
PMCPMC6518405
OpenAlexW2938839216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.