ArticlePloS one2019
The interplay between cerebellum and basal ganglia in motor adaptation: A modeling study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Modulation of error sensitivity during motor learning across time, space and environment variability.bioRxiv : the preprint server for biology · 2025Article
- The engagement of the cerebellum and basal ganglia enhances expertise in a sensorimotor adaptation task.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A novel tablet-based motor coordination test performs on par with the Beery VMI subtest and offers superior temporal metrics: findings from children with pediatric acute-onset neuropsychiatric syndrome.Experimental brain research · 2023Article
- The contribution of the basal ganglia and cerebellum to motor learning: A neuro-computational approach.PLoS computational biology · 2023Article
- Directed information flow during laparoscopic surgical skill acquisition dissociated skill level and medical simulation technology.NPJ science of learning · 2022Article
- Training a spiking neuronal network model of visual-motor cortex to play a virtual racket-ball game using reinforcement learning.PloS one · 2022Article
- Exploration of sensory-motor tradeoff behavior in Parkinson's disease.Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor adaptation to perturbations is provided by learning mechanisms operating in the cerebellum and basal ganglia. The cerebellum normally performs motor adaptation through supervised learning using information about movement error provided by visual feedback. However, if visual feedback is critically distorted, the system may disengage cerebellar error-based learning and switch to reinforcement learning mechanisms mediated by basal ganglia. Yet, the exact conditions and mechanisms of cerebellum and basal ganglia involvement in motor adaptation remain unknown. We use mathematical modeling to simulate control of planar reaching movements that relies on both error-based and non-error-based learning mechanisms. We show that for learning to be efficient only one of these mechanisms should be active at a time. We suggest that switching between the mechanisms is provided by a special circuit that effectively suppresses the learning process in one structure and enables it in the other. To do so, this circuit modulates learning rate in the cerebellum and dopamine release in basal ganglia depending on error-based learning efficiency. We use the model to explain and interpret experimental data on error- and non-error-based motor adaptation under different conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.