Evidence map›Paper›PMID 30977904›Full record

Trial reportAlcoholism, clinical and experimental research2019

Mindfulness-Based Relapse Prevention and Transcranial Direct Current Stimulation to Reduce Heavy Drinking: A Double-Blind Sham-Controlled Randomized Trial.

Katie Witkiewitz, Elena R Stein, Victoria R Votaw, Adam D Wilson, Corey R Roos, Stevi J Gallegos, Vincent P Clark, Eric D Claus

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alcoholism, clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02861807 nacompletednot on this map

Mindfulness-Based Intervention and Transcranial Direct Current Brain Stimulation to Reduce Heavy Drinking: Efficacy and Mechanisms of Change

TypeinterventionalSponsorUniversity of New MexicoRan2016 to 2018Enrolled84ConditionsAlcohol Drinking, Alcohol Intoxication, AlcoholismArmsBrain stimulation with mindfulness-based relapse prevention
NCT05579210 nacompletednot on this mapstarted 2022, after this paper: background citation

Developing and Implementing an Online Relapse Prevention Psychotherapy Program for Patients With Alcohol Use Disorder

TypeinterventionalSponsorDr. Nazanin AlaviRan2022 to 2024Enrolled60ConditionsAlcohol Use DisorderArmsOnline relapse prevention therapy, Face to face relapse prevention therapy
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Pooled it
  2. Examining replicability in addictions research: How to assess and ways forward.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022
    Pooled it
  3. Mindfulness-based interventions for substance use disorders.The Cochrane database of systematic reviews · 2021
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  10. Mindful attention promotes control of brain network dynamics for self-regulation and discontinues the past from the present.Proceedings of the National Academy of Sciences of the United States of America · 2023
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  15. Using Electroencephalography to Advance Mindfulness Science: A Survey of Emerging Methods and Approaches.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katie WitkiewitzDepartment of Psychology, University of New Mexico, Albuquerque, New Mexico.ORCID 0000-0002-1086-3067
Elena R SteinDepartment of Psychology, University of New Mexico, Albuquerque, New Mexico.
Victoria R VotawDepartment of Psychology, University of New Mexico, Albuquerque, New Mexico.
Adam D WilsonDepartment of Psychology, University of New Mexico, Albuquerque, New Mexico.
Corey R RoosDepartment of Psychology, University of New Mexico, Albuquerque, New Mexico.
Stevi J GallegosDepartment of Psychology, University of New Mexico, Albuquerque, New Mexico.
Vincent P ClarkDepartment of Psychology, University of New Mexico, Albuquerque, New Mexico.
Eric D ClausMind Research Network, Albuquerque, New Mexico.ORCID 0000-0002-1800-0813

Funding

Alcohol Research Training: Methods & MechanismsT32AA018108 · NIAAA · UNIVERSITY OF NEW MEXICO · PI Katie A Witkiewitz · 2010 to 2026
$5.6M
Mindfulness-Based Intervention and Transcranial Direct Current Brain Stimulation to Reduce Heavy Drinking: Efficacy and Mechanisms of ChangeR21AA024926 · NIAAA · UNIVERSITY OF NEW MEXICO · PI WITKIEWITZ, KATIE A · 2016 to 2017
$409k
The role of brain-derived neurotrophic factor in the link between physical activity and psychosocial recovery from alcohol use disorderF31AA026773 · NIAAA · UNIVERSITY OF NEW MEXICO · PI WILSON, ADAM DEFOREST · 2018 to 2019
$71k
NIAAA NIH HHS F31 AA026773NIAAA NIH HHS R21 AA024926NIAAA NIH HHS T32 AA018108
6 · The paper itself

Abstract

backgroundMindfulness-based relapse prevention (MBRP) and transcranial direct current stimulation (tDCS) have independently shown benefits for treating alcohol use disorder (AUD). Recent work suggests tDCS may enhance mindfulness. The combination of MBRP and tDCS may provide synergistic benefits and may target both behavioral and neurobiological dysfunctions in AUD. The goal of this double-blind sham-controlled randomized trial was to examine the efficacy of a rolling group MBRP treatment combined with tDCS among individuals interested in reducing their drinking.

methodsIndividuals who were interested in reducing their alcohol use (n = 84; 40.5% female; mean age = 52.3; 98.9% with current AUD) were randomized to receive active (2.0 milliamps) or sham (0.0 milliamps) anodal tDCS (5 cm × 3 cm electrode) of the right inferior frontal gyrus with the 5 cm × 3 cm cathodal electrode applied to the left upper arm, combined with 8 weeks of outpatient MBRP rolling group treatment. Assessments were conducted at baseline, posttreatment, and 2 months following treatment. The primary outcome was drinks per drinking day, and secondary outcomes were percent heavy drinking days, self-reported craving, alcohol cue reactivity in an alcohol cue task, and response inhibition in a stop signal reaction time task.

resultsResults indicated significant reductions in drinks per drinking day over time, B(SE) = -0.535 (0.16), p = 0.001, and a significant dose effect for number of groups attended, B(SE) = -0.259 (0.11), p = 0.01. There were also significant effects of time and dose for number of groups attended on secondary outcomes of percent heavy drinking days and alcohol cue reactivity. There were no effects of active versus sham tDCS on primary or secondary outcomes.

conclusionsFindings from the current study provide initial support for the effectiveness of rolling group MBRP as an outpatient treatment for drinking reduction. The current study did not find additive effects of this tDCS protocol in enhancing MBRP among individuals with drinking reduction goals.

Indexed as

MindfulnessTranscranial Direct Current StimulationAdultAgedAlcoholismDouble-Blind MethodFemaleHumansMaleMiddle AgedSecondary PreventionYoung AdultAlcohol Use DisorderDrinking ReductionMindfulness-Based Relapse PreventionRolling Group TreatmentTranscranial Direct Current Stimulation

Identifiers

PMID30977904
PMCPMC6551269

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.