ReviewBiotechnology journal2019
Engineered Skin Tissue Equivalents for Product Evaluation and Therapeutic Applications.
Review in Biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- 3D Bioprinted Alginate-Gelatin-Collagen Based Hydrogels Laden With Fibroblast and Keratinocyte Cells Show Potential for Regeneration of Injured Skin.Macromolecular bioscience · 2026Article
- Potential of 3D Skin Models and N/TERT-2G Cell Line in Genetic Research on Autosomal Recessive Nonsyndromic Epidermal Differentiation Disorders.Experimental dermatology · 2026Article
- Innovations in skin microphysiological systems for nonclinical testing and FDA modernization.Microsystems & nanoengineering · 2026Review
- A novel integratedRegenerative biomaterials · 2026Article
- Skin-on-chip: Quo vadis?APL bioengineering · 2025Review
- A dermis-on-a-chip model for compound screening.Materials today. Bio · 2025Article
- Study of the Effectiveness of Skin Restoration Using a Biopolymer Hydrogel Scaffold with Encapsulated Mesenchymal Stem Cells.International journal of molecular sciences · 2025Article
- Low molecular weight fucoidan differentiation media enhances quality and extents shelf life of 3D human skin model.Scientific reports · 2025Article
- Inhibitory effects of corylin derived from aerial part of Pueraria lobata on melanin synthesis and potential applications in skin whitening and photoaging management.Natural products and bioprospecting · 2025Article
- Integrating melt electrowriting (MEW) PCL scaffolds with fibroblast-laden hydrogel toward vascularized skin tissue engineering.Materials today. Bio · 2025Article
- Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Poly-γ-Glutamic Acid from a NovelInternational journal of molecular sciences · 2025Article
- 3D human epithelial models: a promising platform for studyingFrontiers in cellular and infection microbiology · 2025Article
- Organoids/organs-on-chips towards biomimetic human artificial skin.Burns & trauma · 2025Review
- Development of pathological skin models: from conventional techniques to 3D bioprinting.Frontiers in bioengineering and biotechnology · 2025Review
- Bioinspired skin-like in vitro model for investigating catheter-related bloodstream infections.Scientific reports · 2024Article
- The emerging progress on wound dressings and their application in clinic wound management.Heliyon · 2023Review
- Intradermal Delivery of Naked mRNA Vaccines via Iontophoresis.Pharmaceutics · 2023Review
- Creation of Chemically Tri-Layered Collagen Crosslinked Membranes and Their Comparison with Ionically Tri-Layered Chitosan Crosslinked Membranes to Study Human Skin Properties.International journal of molecular sciences · 2023Article
- Three-Dimensional Cell Cultures: The Bridge between In Vitro and In Vivo Models.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The current status of skin tissue equivalents that have emerged as relevant tools in commercial and therapeutic product development applications is reviewed. Due to the rise of animal welfare concerns, numerous companies have designed skin model alternatives to assess the efficacy of pharmaceutical, skincare, and cosmetic products in an in vitro setting, decreasing the dependency on such methods. Skin models have also made an impact in determining the root causes of skin diseases. When designing a skin model, there are various chemical and physical considerations that need to be considered to produce a biomimetic design. This includes designing a structure that mimics the structural characteristics and mechanical strength needed for tribological property measurement and toxicological testing. Recently, various commercial products have made significant progress towards achieving a native skin alternative. Further research involve the development of a functional bilayered model that mimics the constituent properties of the native epidermis and dermis. In this article, the skin models are divided into three categories: in vitro epidermal skin equivalents, in vitro full-thickness skin equivalents, and clinical skin equivalents. A description of skin model characteristics, testing methods, applications, and potential improvements is presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.