ArticleTrends in hearing
Age-Related Changes in the Auditory Brainstem Response and Suprathreshold Processing of Temporal and Spectral Modulation.
Article in Trends in hearing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of age and noise exposure history on auditory nerve response amplitudes: A systematic review, study, and meta-analysis.Hearing research · 2024Pooled it
- The impact of age-related hearing loss on structural neuroanatomy: A meta-analysis.Frontiers in neurology · 2022Pooled it
- Detecting Noise-Induced Cochlear Synaptopathy by Auditory Brainstem Response in Tinnitus Patients With Normal Hearing Thresholds: A Meta-Analysis.Frontiers in neuroscience · 2021Pooled it
- Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition.Neurobiology of aging · 2026Article
- Aging effects on the neural representation and perception of consonant transition cues.Hearing research · 2024Article
- Neurometric amplitude modulation detection in the inferior colliculus of Young and Aged rats.Hearing research · 2024Article
- Effects of Age and Noise Exposure History on Auditory Nerve Response Amplitudes: A Systematic Review, Study, and Meta-Analysis.bioRxiv : the preprint server for biology · 2024Article
- Neural hyperactivity and altered envelope encoding in the central auditory system: Changes with advanced age and hearing loss.Hearing research · 2024Review
- Article
- Factors Related to the Progression of Clinically Isolated Syndrome to Multiple Sclerosis: A Retrospective Study in Lithuania.Medicina (Kaunas, Lithuania) · 2022Article
- Age-related central gain with degraded neural synchrony in the auditory brainstem of mice and humans.Neurobiology of aging · 2022Article
- [Electrophysiological study of the cochlea in patients with unilateral acute tinnitus].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Article
- The Relative and Combined Effects of Noise Exposure and Aging on Auditory Peripheral Neural Deafferentation: A Narrative Review.Frontiers in aging neuroscience · 2022Review
- Neural Presbyacusis in Humans Inferred from Age-Related Differences in Auditory Nerve Function and Structure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Peripheral deficits and phase-locking declines in aging adults.Hearing research · 2021Article
- Effects of age on psychophysical measures of auditory temporal processing and speech reception at low and high levels.Hearing research · 2021Article
- Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome.Frontiers in aging neuroscience · 2021Article
- Age-Dependent Auditory Processing Deficits after Cochlear Synaptopathy Depend on Auditory Nerve Latency and the Ability of the Brain to Recruit LTP/BDNF.Brain sciences · 2020Article
- Effects of age on electrophysiological measures of cochlear synaptopathy in humans.Hearing research · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The purpose of this study was to determine whether cochlear synaptopathy can be shown to be a viable basis for age-related hearing difficulties in humans and whether it manifests as deficient suprathreshold processing of temporal and spectral modulation. Three experiments were undertaken evaluating the effects of age on (a) the auditory brainstem response as a function of level, (b) temporal modulation detection as a function of level and background noise, and (c) spectral modulation as a function of level. Across the three experiments, a total of 21 older listeners with near-normal audiograms and 29 young listeners with audiometrically normal hearing participated. The auditory brainstem response experiment demonstrated reduced Wave I amplitudes and concomitant reductions in the amplitude ratios of Wave I to Wave V in the older listener group. These findings were interpreted as consistent with an electrophysiological profile of cochlear synaptopathy. The temporal and spectral modulation detection experiments, however, provided no support for the hypothesis of compromised suprathreshold processing in these domains. This pattern of results suggests that even if cochlear synaptopathy can be shown to be a viable basis for age-related hearing difficulties, then temporal and spectral modulation detection paradigms are not sensitive to its presence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.