Evidence map›Paper›PMID 30977439›Full record

ReviewOpen biology2018

The diverse small proteins called odorant-binding proteins.

Jennifer S Sun, Shuke Xiao, John R Carlson

Abstract readReview
In one paragraph

Review in Open biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed.

  1. Review
  2. Antennal Responses and Odorant-Binding Protein 7 Binding ofInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Beyond olfaction: New insights into human odorant binding proteins.Protein science : a publication of the Protein Society · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennifer S SunDepartment of Molecular, Cellular and Developmental Biology, Yale University , New Haven, CT 06520 , USA.
Shuke XiaoDepartment of Molecular, Cellular and Developmental Biology, Yale University , New Haven, CT 06520 , USA.
John R CarlsonDepartment of Molecular, Cellular and Developmental Biology, Yale University , New Haven, CT 06520 , USA.

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007499 · NIGMS · YALE UNIVERSITY · PI CARLSON, JOHN R, REINKE, VALERIE J · 1985 to 2022
$13.9M
ANALYSIS OF ODORANT RECEPTOR GENESR01DC004729 · NIDCD · YALE UNIVERSITY · PI John R Carlson · 2001 to 2026
$9.2M
GENETIC AND MOLECULAR ANALYSIS OF OLFACTIONR01DC002174 · NIDCD · YALE UNIVERSITY · PI CARLSON, JOHN R · 1994 to 2024
$8.0M
NIDCD NIH HHS R01 DC002174NIDCD NIH HHS R01 DC004729NIGMS NIH HHS T32 GM007499
6 · The paper itself

Abstract

The term 'odorant-binding proteins (Obps)' is used to refer to a large family of insect proteins that are exceptional in their number, abundance and diversity. The name derives from the expression of many family members in the olfactory system of insects and their ability to bind odorants in vitro. However, an increasing body of evidence reveals a much broader role for this family of proteins. Recent results also provoke interesting questions about their mechanisms of action, both within and outside the olfactory system. Here we describe the identification of the first Obps and some cardinal properties of these proteins. We then consider their function, discussing both the prevailing orthodoxy and the increasing grounds for heterodox views. We then examine these proteins from a broader perspective and consider some intriguing questions in need of answers.

Indexed as

AnimalsInsectaInsect ProteinsModels, MolecularMultigene FamilyProtein Structure, SecondaryReceptors, OdorantInsect Proteinsodorant-binding proteinReceptors, OdorantantennaDrosophilainsectodorant-binding proteinolfaction

Identifiers

PMID30977439
PMCPMC6303780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.