ArticleJournal of biomedical optics2019
Unraveling the molecular nature of melanin changes in metastatic cancer.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- From Monomers to Aggregates: The Influence of Redox State and Structure on the First Excited States of Eumelanin and Pheomelanin.International journal of molecular sciences · 2026Article
- Galvanometer-scanning transient phase microscopy with balanced detection and arbitrary pump polarization.Journal of the Optical Society of America. B, Optical physics · 2026Article
- Angle-resolved Measurements Reveal the Origin of Signal Anisotropy in Pump-probe Microscopy.bioRxiv : the preprint server for biology · 2025Article
- Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023Article
- Recent Advances in Characterization of Melanin Pigments in Biological Samples.International journal of molecular sciences · 2023Review
- Contrast mechanisms in pump-probe microscopy of melanin.Optics express · 2022Article
- Synthesis of soluble melanin nanoparticles under acidic conditions usingRSC advances · 2022Article
- Laccase Mediator Cocktail System as a Sustainable Skin Whitening Agent for Deep Eumelanin Decolorization.International journal of molecular sciences · 2022Article
- The Photophysics and Photochemistry of Melanin- Like Nanomaterials Depend on Morphology and Structure.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
- Advanced Electron Microscopy of Nanophased Synthetic Polymers and Soft Complexes for Energy and Medicine Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- From Melanocytes to Melanoma Cells: Characterization of the Malignant Transformation by Four Distinctly Different Melanin Fluorescence Spectra (Review).International journal of molecular sciences · 2021Review
- Leaving the Limits of Linearity for Light Microscopy.The journal of physical chemistry. C, Nanomaterials and interfaces · 2020Article
- Probing the heterogeneous structure of eumelanin using ultrafast vibrational fingerprinting.Nature communications · 2020Article
- Melanin distribution from the dermal-epidermal junction to the stratum corneum: non-invasive in vivo assessment by fluorescence and Raman microspectroscopy.Scientific reports · 2020Article
- Transient absorption microscopy: Technological innovations and applications in materials science and life science.The Journal of chemical physics · 2020Article
- Special Section Guest Editorial: Celebration of the Britton Chance Legacy.Journal of biomedical optics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
More people die from melanoma after a stage I diagnosis than after a stage IV diagnosis, because the tools available to clinicians do not readily identify which early-stage cancers will be aggressive. Near-infrared pump-probe microscopy detects fundamental differences in melanin structure between benign human moles and melanoma and also correlates with metastatic potential. However, the biological mechanisms of these changes have been difficult to quantify, as many different mechanisms can contribute to the pump-probe signal. We use model systems (sepia, squid, and synthetic eumelanin), cellular uptake studies, and a range of pump and probe wavelengths to demonstrate that the clinically observed effects come from alterations of the aggregated mode from "thick oligomer stacks" to "thin oligomer stacks" (due to changes in monomer composition) and (predominantly) deaggregation of the assembled melanin structure. This provides the opportunity to use pump-probe microscopy for the detection and study of melanin-associated diseases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.