Evidence map›Paper›PMID 30977191›Full record

ReviewImmunological reviews2019

T-cell positioning by chemokines in autoimmune skin diseases.

Jillian M Richmond, James P Strassner, Kingsley I Essien, John E Harris

Open access · greenAbstract readReview
In one paragraph

Review in Immunological reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Circulating memory T cells and TCF1Journal of pharmaceutical analysis · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Signaling pathways and targeted therapies for psoriasis.Signal transduction and targeted therapy · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Exploring Mast Cell-CD8 T Cell Interactions in Inflammatory Skin Diseases.International journal of molecular sciences · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jillian M RichmondDepartment of Dermatology, UMass Medical School, Worcester, Massachusetts.
James P StrassnerDepartment of Dermatology, UMass Medical School, Worcester, Massachusetts.
Kingsley I EssienDepartment of Dermatology, UMass Medical School, Worcester, Massachusetts.
John E HarrisDepartment of Dermatology, UMass Medical School, Worcester, Massachusetts.ORCID 0000-0002-7815-6430
University of Massachusetts Chan Medical School · US

Funding

Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
Treg Migration and Function During Autoimmunity within Peripheral TissueR01AR069114 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HARRIS, JOHN E · 2015 to 2020
$2.2M
Training in the Molecular Basis of Autoimmunity and AutoinflammationT32AI132152 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Katherine A. Fitzgerald, Ann Marshak-Rothstein · 2018 to 2026
$1.6M
Dissecting autoimmune cellular and molecular networks in vitiligoR61AR073042 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GARBER, MANUEL, HARRIS, JOHN E · 2017 to 2018
$838k
NIAID NIH HHS T32 AI095213NIAID NIH HHS T32 AI132152NIAMS NIH HHS R01 AR069114NIAMS NIH HHS R61 AR073042NIH HHS AR07302
6 · The paper itself

Abstract

Autoimmune skin diseases are complex processes in which autoreactive cells must navigate through the skin tissue to find their targets. Regulatory T cells in the skin help to mitigate autoimmune inflammation and may in fact be responsible for the patchy nature of these conditions. In this review, we will discuss chemokines that are important for global recruitment of T cell populations to the skin during disease, as well as signals that fine-tune their localization and function. We will describe prototypical disease responses and chemokine families that mediate these responses. Lastly, we will include an overview of chemokine-targeting drugs that have been tested as new treatment strategies for autoimmune skin diseases.

Indexed as

AnimalsAutoimmune DiseasesCell MovementChemokinesHumansImmunity, CellularImmunotherapyMolecular Targeted TherapySignal TransductionSkin DiseasesT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsChemokinesautoimmunitycell traffickingchemokinesskinT cellstype 1/type 2/type 17 responses

Identifiers

PMID30977191
PMCPMC6553463
OpenAlexW2939514948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.